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FLASH GENE
Symbol ESM1 contributors: npt/ - updated : 17-09-2004
HGNC name endothelial cell-specific molecule 1
HGNC id 3466
Location 5q11.2      Physical location : 54.273.695 - 54.281.414
Synonym name
  • endocan
  • ESM-1 secretory protein
    • DNA
    TYPE functioning gene
    STRUCTURE 7.27 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D5S491 - IL6ST - ESM1 - CKN1 - D5S427 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2089 18 184 - -
    - - 1939 12.5 134 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal domain cysteine-rich
  • a C terminal tail free of cysteine residues
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • chondroitin sulfate/dermatan sulfate proteoglycan promoting hepatocyte growth factor/scatter factor mitogenic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by TNF, IL1B and IFNG
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS