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FLASH GENE
Symbol ERN2 contributors: SGE/npt - updated : 22/10/2008
HGNC name endoplasmic reticulum to nucleus signaling 2
HGNC id 16942
Location 16p12.2      Physical location : 23.701.627 - 23.724.821
Synonym name
  • IRE1 beta
  • IRE1, S. cerevisiae, homolog of
  • inositol-requiring protein 2
  • inositol-requiring 1 beta
  • Synonym symbol(s) IRE1b, Ire1-beta
    EC.number 2.7.11.1, 3.1.26.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation, tail to tail
    text located 55bp from PLK
    STRUCTURE 23.20 kb     22 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3634 107.1 974 - Wang (1998)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     mouth   highly
     stomach   moderately
    Respiratoryrespiratory tracttrachea  predominantly
    Urinarybladder   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 34 aa signal peptide
  • a kinase domain activated by trans-autophosphorylation
  • a KEN domain
  • a protein kinase domain
  • HOMOLOGY
    interspecies homolog to rattus Ern2 (82.0 pc)
    homolog to murine Ern2 (82.8 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text single-pass type I membrane protein
    basic FUNCTION
  • activating the endogenous ER chaperones
  • inducing translational repression through 28S ribosomal RNA cleavage in response to ER stress
  • having a pro-apoptotic activity
  • kinase activity required for activation of the endoribonuclease domain
  • acting as an endonuclease that producing 5'-phosphomonoesters
  • mediating a partial translational attenuation of XBP1 (Imagawa 2008)
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text
  • induction of apoptosis
  • negative regulation of transcription
  • cell cycle arrest
  • PATHWAY
    metabolism nucleic
    signaling
    rRNA catabolic process
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
  • protein
  • NR2F1 and ERN2 suppress MTTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cell
  • cell & other
    REGULATION
    Other autophosphorylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS