protein
| TRAF2 was proposed to bind to ERN1 during ER stress response |
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binds HSPA5, a negative regulator of the unfolded protein response (interaction may disrupt homodimerization and prevent activation of ERN1) |
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CD59 (complement defense 59) mRNA is a novel cleavage target of ERN1 |
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directly binds to USP14 and the interaction between ERN1 and USP14 is inhibited by ER stress |
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HSPA1A binding to ERN1 enhances ERN1/XBP1 signaling at the ER and inhibits ER stress-induced apoptosis |
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ERN1 target XBP1, and are essential for bone morphogenic protein 2-induced osteoblast differentiation |
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directs proteasomal and lysosomal degradation of misfolded rhodopsin |
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spliced XBP1 serves as an important effector of ERN1, activating its target genes |
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in contrast to its mode of binding ATF6 and unfolded proteins, HSPA5 binds to ERN1 and EIF2AK3 in a different manner |
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ERN1/XBP1 controls the induction of autophagy by activating the expression of the ER membrane transporter SLC33A1, which ensures continuous supply of acetyl-CoA into the lumen of the ER |
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PARP16 is a tail-anchored ER transmembrane protein required for activation of the functionally related ER stress sensors EIF2AK3 and ERN1 |
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IRAK2 is a novel amplifier of the ERN1 pathway |
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RNF13-ERN1 interaction increased the stability of ERN1 |
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ERN1, ATF6, and EIF2AK3 signaling pathways, collectively called the unfolded protein response (UPR), regulate the functions of endoplasmic reticulum, responsible for accurate folding of membrane proteins such as RHO |
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NMI is an ERN1-interacting/modulator protein in human pancreatic beta cells |
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indirectly RIPK1 regulates likely CASP8 activation, in part via interaction with the ER stress sensor inositol-requiring protein 1 (ERN1) |
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novel function of ERN1 in the regulation of EIF2S1 phosphorylation and the translational control |
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acute METTL14 deficiency in beta-cells induces glucose intolerance by increasing the ERN1/XBP1 pathway |
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depletion of CREB1 decreased the expression of ERN1 and EIF2AK3, two critical UPR signaling molecules, and CREB1 binds to the promoter region of these genes and regulates their expression |
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ERN1 signaling is quite context-specific on account of many adaptor and modulator proteins that directly interact with it, including heat shock proteins (HSPs), RNF13, PARP16, TMBIM6 |
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DDRGK1 regulates ERN1 protein stability via its interaction with the kinase domain of ERN1, which is dependent on its ufmylation modification |
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MARCH5 inhibits ER stress-induced apoptosis through ubiquitylation of ERN1 at the mitochondria-associated ER membrane (MAM) |
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