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FLASH GENE
Symbol ERAP2 contributors: mct/npt/pgu - updated : 15-04-2014
HGNC name endoplasmic reticulum aminopeptidase 2
HGNC id 29499
Location 5q15      Physical location : 96.211.643 - 96.255.398
Synonym name
  • leukocyte-derived arginine aminopeptidase
  • endoplasmic reticulum aminopeptidase 2
  • Synonym symbol(s) L-RAP, FLJ23633, FLJ23701, LRAP, FLJ23807
    EC.number 3.4.11.-
    DNA
    TYPE functioning gene
    STRUCTURE 43.76 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 both the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 5254 - 960 - 2005 15908954
    19 - 5691 - 960 - 2005 15908954
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Lymphoid/Immunethymus   highly
     tonsils   highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidneyrenal medulla    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentralwhite matter  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunenatural killer
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a HEXXH(X)18E zinc-binding motif, which is characteristic of the M1 family of zinc metallopeptidases
  • HOMOLOGY
    intraspecies homolog to ARTS1
    paralog to ERAP1
    Homologene
    FAMILY
  • oxytocinase subfamily of aminopeptidases
  • peptidase M1 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • located in the lumenal side of the endoplasmic reticulum
  • localized in the cytosol and ER with its major C-terminal part and active site in the ER lumen
  • basic FUNCTION
  • aminopeptidase that can trim the N-terminal extended precursors to antigenic peptides in the endoplasmic reticulum
  • play a role in blood pressure regulation and essential hypertension in addition to innate immune and inflammatory responses
  • ERAP1, ERAP2, LNPEP play critical roles in the generation of antigenic peptides
  • plays potentially a role in the development of preeclampsia
  • requirement of LNPEP in cross-presentation extends to steady-state conventional dendritic cells
  • ERAP1 and ERAP2 cooperate to trim antigenic peptide precursors for loading onto MHC class I molecules and help regulate the adaptive immune response
  • ERAP1 and ERAP2 might play an important role in shaping the MHC class I-presented peptide repertoire
  • ERAP1 and ERAP2 might be involved in the development of immune escape mechanisms of renal cell carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated physically with ERAP1 in complexes that were most likely heterodimeric
  • association between ERAP2 and EPCAM is a unique and novel finding that provides new ideas on EPCAM processing and on how antigen presentation may be regulated in cancer
  • cell & other
    REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to preeclampsia
  • to Crohn disease
  • to viral and bacterial infections, autoimmunity and cancer with altered antigen processing
  • Variant & Polymorphism SNP
  • associated with preeclampsia
  • increasing the risk of Crohn disease
  • SNP inducing a specificity switch that leads to altered antigen processing
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS