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FLASH GENE
Symbol EPS8L3 contributors: mct - updated : 26-06-2019
HGNC name EPS8-like 3
HGNC id 21297
Corresponding disease
HMU2 hypotrichosis, Marie Unna type 2
Location 1p13.3      Physical location : 110.292.701 - 110.306.564
Synonym name
  • EPS8-related protein 3
  • epidermal growth factor receptor pathway substrate 8-related protein 3
  • Synonym symbol(s) FLJ21522, MGC16817, EPS8R3
    DNA
    TYPE functioning gene
    STRUCTURE 13.89 kb     19 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2222 - 594 - 2014 24236410
    19 - 2219 - 593 - 2014 24236410
    19 - 2129 - 563 - 2014 24236410
    18 - 2077 - 530 - 2014 24236410
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
     stomach    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal PTB domain
  • C terminal SH3 domain
  • HOMOLOGY
    interspecies homolog to drosophila Aru
    Homologene
    FAMILY
  • EPS8 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • enhancing EGF-dependent mitogenic signals
  • role of EPS8L3 in memory
  • has a role in classically conditioned olfactory memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • might likely promote proliferation by hyperactivating the AKT1 signaling pathway and subsequently inhibiting the FOXO1 transcriptional activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMU2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC) tissues and cell lines compared with the normal liver tissues and cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may be a novel therapeutic target for HCC
    ANIMAL & CELL MODELS