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FLASH GENE

Symbol

EPS8L1

contributors: mct - updated : 18-01-2013

HGNC name	EPS8-like 1
HGNC id	21295

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.42      Physical location : 55.587.220 - 55.599.290
Synonym name	epidermal growth factor receptor pathway substrate 8-related protein 1
	EPS8-related protein 1
Synonym symbol(s)	MGC4642, FLJ20258, EPS8R1, MGC23164

DNA

TYPE	functioning gene
STRUCTURE	11.77 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_133180 20 - 2607 NP_573441 - 723 - 2012 22262457 EPS8L1A ezrin-interacting partner, controling microvillus length through its capping activity NM_017729 15 - 2224 NP_060199 - 596 - 2012 22262457 EPS8L1B variant 3 - - 2162 - 551 - 2012 22262457

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas           thyroid         Reproductive male system prostate       Respiratory lung           respiratory tract larynx       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal PTB domain
	one PH domain
	one SH3 domain

HOMOLOGY

Homologene

FAMILY

EPS8 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	coexpression of EZR with EPS8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of EZR and EPS8L1A induces the clustering of actin-containing structures at the cell surface

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	strong binding of CD3epsilon to EPS8L1 and NCK1 SH3 domains
	CD3epsilon peptide binds EPS8L1 SH3 in a class II orientation, but neither adopts a polyproline II helical conformation nor engages the first proline-binding pocket of the SH3 ligand binding interface
	ezrin differentially modulates the actin-capping and -bundling activities of EPS8 and EPS8L1a during microvillus assembly

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS