Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EPS8L1 contributors: mct - updated : 18-01-2013
HGNC name EPS8-like 1
HGNC id 21295
Location 19q13.42      Physical location : 55.587.220 - 55.599.290
Synonym name
  • epidermal growth factor receptor pathway substrate 8-related protein 1
  • EPS8-related protein 1
  • Synonym symbol(s) MGC4642, FLJ20258, EPS8R1, MGC23164
    DNA
    TYPE functioning gene
    STRUCTURE 11.77 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390973 19 similar to killer-cell Ig-like receptor KIR3DL7 KIR2DL1 19q13.4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 LOC390974 19 similar to 1060P11.3 (killer inhibitory receptor 2-2-2 (KIR222) (KIRX)) LOC388562 19 similar to 1060P11.4.2 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (isoform 2) (KIR103-AS)) KIR3DL1 19q13.4 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 KIR2DS4 19q13.4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 FCAR 19q13.4 Fc fragment of IgA, receptor for NCR1 19q13.42 natural cytotoxicity triggering receptor 1 NALP7 19q13.42 NACHT, leucine rich repeat and PYD containing 7 NALP2 19q13.42 NACHT, leucine rich repeat and PYD containing 7 GP6 19q13.4 glycoprotein VI (platelet) RDH13 19q13.42 retinol dehydrogenase 13 (all-trans and 9-cis) EPS8L1 19q13.42 EPS8-like 1 PPP1R12C 19q13.42 protein phosphatase 1, regulatory (inhibitor) subunit 12C TNNT1 19q13.4 troponin T1, skeletal, slow TNNI3 19q13.4 troponin I, cardiac LOC352909 19q13.4 similar to hypothetical testis protein from macaque SYT5 19q13.4 synaptotagmin V PTPRH 19q13.4 protein tyrosine phosphatase, receptor type, H LOC388563 19 LOC388563 MGC30208 19q13.42 hypothetical protein MGC30208 KIAA1115 19q13.42 KIAA1115
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2607 - 723 - 2012 22262457
  • EPS8L1A
  • ezrin-interacting partner, controling microvillus length through its capping activity
  • 15 - 2224 - 596 - 2012 22262457
    EPS8L1B
    - - 2162 - 551 - 2012 22262457
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
     thyroid    
    Reproductivemale systemprostate   
    Respiratorylung    
     respiratory tractlarynx   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal PTB domain
  • one PH domain
  • one SH3 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • EPS8 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text coexpression of EZR with EPS8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of EZR and EPS8L1A induces the clustering of actin-containing structures at the cell surface
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • strong binding of CD3epsilon to EPS8L1 and NCK1 SH3 domains
  • CD3epsilon peptide binds EPS8L1 SH3 in a class II orientation, but neither adopts a polyproline II helical conformation nor engages the first proline-binding pocket of the SH3 ligand binding interface
  • ezrin differentially modulates the actin-capping and -bundling activities of EPS8 and EPS8L1a during microvillus assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS