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FLASH GENE
Symbol EPN1 contributors: mct/npt - updated : 27-04-2012
HGNC name epsin 1
HGNC id 21604
Location 19q13.42      Physical location : 56.186.560 - 56.207.132
Synonym name
  • EH domain-binding mitotic phosphoprotein
  • EPS-15-interacting protein 1
  • Synonym symbol(s) EPSIN
    DNA
    TYPE functioning gene
    STRUCTURE 20.57 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2964 - 662 - 2003 12750376
    11 - 2501 - 576 - 2003 12750376
    10 - 2423 - 550 - 2003 12750376
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Nervousnerve   highly
    Reproductivemale systemprostate  highly
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • epsin N-terminal homology (ENTH) domain (ENTH domains comprise multiple alpha-helices folded upon each other to form a compact globular structure that has been implicated in interactions with lipids and proteins) , and contains an additional N-terminal hydrophobic alpha0 helix
  • two or three ubiquitin-interacting motifs (UIMs)
  • two clathrin binding sequences
  • several AP2-binding sites
  • several Eps15 homology (EH) domain binding motif, that function in vesicular trafficking and endocytosis
  • three Arg-Pro-Phe (NPF) motifs in the C terminal region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to rattus Epn1
    Homologene
    FAMILY
  • epsin family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • accumulated at synaptic coated pits
  • within the synaptic compartments, distributed similarly throughout
  • basic FUNCTION
  • playing a role in clathrin-mediated endocytosis of synaptic vesicles
  • may act as an alternate adaptor in several endocytic pathways
  • involved in clathrin-mediated synaptic vesicle endocytosis (an additional mechanism for generation of uniformly sized synaptic vesicles)
  • EPN1 and huntingtin-interacting protein 1 (HIP1) are endocytic accessory proteins (
  • EPN1 and HIP1 in the synapse: as broadly required factors for promoting clathrin assembly and as adaptors for specific endocytic pathways
  • participatong in clathrin-mediated synaptic vesicle endocytosis at a central synapse
  • promotes endocytosis of the ubiquitinated EGFR
  • endocytic adaptor with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins
  • role of epsin as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling
  • endocytic adapter protein, regulating mitotic membrane morphology and spindle integrity
  • epsin-induced membrane curvature is required for proper spindle morphogenesis, independent of its function in endocytosis during interphase
  • adaptor protein complex-2 and EPN1 are both critical mediators of agonist-stimulated F2R internalization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • coat component in several clathrin-mediated endocytic pathways
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to AP-2
  • binding to EPS15
  • binding to POB1 (to the EH domain)
  • interacted with ubiquitinated EGFR and functional UIMs were essential for complex formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS