Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EPHB6 contributors: np/ - updated : 09-03-2007
HGNC name EPH receptor B6
HGNC id 3396
Location 7q34      Physical location : 142.552.791 - 142.568.845
Synonym name
  • EPH-related tyrosine kinase receptor B6
  • tyrosine-protein kinase-defective receptor EPH-6
  • Synonym symbol(s) HEP, MGC129910, MGC129911
    EC.number 2.7.1.112
    DNA
    TYPE functioning gene
    STRUCTURE 16.06 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 4044 110.5 1021 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Nervousnerve   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a vestigial Ig-l domain
  • a protein kinase domain
  • a SAM (sterile alpha motif) domain
  • a single cysteine rich region and two FNIII domains in the extracellular region
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • ephrin receptor
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in short-range contact-mediated axonal guidance
  • can both positively and negatively regulate cell adhesion and migration
  • transduces signals to the nucleus and alters relevant gene expression, resulting in the decrease of invasiness of breast carcinoma cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ephrins B6 binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    silenced in invasive breast carcinoma cells
    tumoral     --over  
    in low stage neuroblastoma with NTRK1 high expression
    tumoral     --low  
    in melanoma in progression to metastatic disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    therapeutic approaches in melanoma
    ANIMAL & CELL MODELS