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FLASH GENE

Symbol

EPHA8

contributors: mct - updated : 30-01-2013

HGNC name	EPH receptor A8
HGNC id	3391

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.12      Physical location : 22.890.003 - 22.930.087
Genatlas name	EPH-related tyrosine kinase receptor 8
Synonym name	EPH- and ELK-related tyrosine kinase
	tyrosine-protein kinase receptor EEK
	tyrosylprotein kinase
Synonym symbol(s)	EEK, HEK3, KIAA1459, EK3
EC.number	2.7.1.112/ 2.7.10.1

DNA

TYPE	functioning gene
STRUCTURE	40.08 kb     17 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020526 17 - 4996 NP_065387 - 1005 - 2012 22291991 NM_001006943 5 - 1866 NP_001006944 - 495 - 2012 22291991

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Lymphoid/Immune spleen         Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a vestigial Ig-I doamin
	a single cysteine rich region
	two fibronectin type-III domains in the extracellular region
	a SAM (sterile alpha motif) domain
	a juxtamembrane region is critically involved in endocytosis of EPHA8-ephrinA5
	complexes.

HOMOLOGY

Homologene

FAMILY

TYR protein kinase family, ephrin receptor subfamily

CATEGORY

enzyme , protooncogene , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

EPHA8 formed a ternary complex with both RINL and ANKS1A

INTERACTION

DNA

RNA

small molecule

protein	possible function for ANKS family proteins (ANKS1A, ANKS1B) as scaffolding proteins of the EPHA8 signaling pathway
	TIAM1 plays a role in clathrin-dependent endocytosis of EPHA8-ephrinA5 complexes
	RINL, as a GEF for RAB5 subfamily, is implicated in the EPHA8-degradation pathway via its interaction with ANKS1A

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS