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FLASH GENE
Symbol EPHA7 contributors: mct - updated : 04-01-2012
HGNC name EPH receptor A7
HGNC id 3390
Location 6q16.1      Physical location : 93.949.741 - 94.129.300
Synonym name Ephrin type-A receptor 7 precursor
Synonym symbol(s) HEK11, EHK3, EPA7
EC.number 2.7.1.112/ 2.7.10.1
DNA
TYPE functioning gene
STRUCTURE 179.56 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • five TCF/LEF-binding sites were identified within the 5prime-promoter region of the EPHA7 gene
  • MAPPING cloned Y linked N status provisional
    Physical map
    GABRR2 6q14-q16.3 gamma-aminobutyric acid (GABA) receptor, rho 2 UBE2J1 6q16.1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) RRAGD 6q15-q16 Ras-related GTP binding D ANKRD6 6q14.2-q16.1 ankyrin repeat domain 6 DJ122O8.2 6q14.2-q16.1 hypothetical protein dJ122O8.2 MDN1 6q15 MDN1, midasin homolog (yeast) CASP8AP2 6q16.1 CASP8 associated protein 2 CX62 6q15-q16 connexin 62 LOC285793 6q16.1 hypothetical LOC285793 BACH2 6q15 BTB and CNC homology 1, basic leucine zipper transcription factor 2 MAP3K7 6q16.1-q16.3 mitogen-activated protein kinase kinase kinase 7 LOC135270 6q16.1 COP9 constitutive photomorphogenic homolog subunit 5 pseudogene EPHA7 6q16.1 EphA7 HCP17 6q16.1 cytochrome c, somatic pseudogene MANEA 6q16.2 mannosidase, endo-alpha LOC134581 6q16.3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FUT9 6q16 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) KIAA0776 6q16.2 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) FHL5 6q16.1-q16.3 four and a half LIM domains 5 LOC391953 6 similar to 40S ribosomal protein S7 (S8) GPR63 6q16.1-q16.3 G protein-coupled receptor 63 C6orf66 6q16.3 chromosome 6 open reading frame 66 KIAA1900 6q16.3 KIAA1900 C6orf167 6q16.3 chromosome 6 open reading frame 167
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 6644 - 998 - 2007 15902206
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   moderately Homo sapiens
    Digestiveintestinesmall intestine  predominantly
    Nervousbrain   moderately
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SAM domain
  • two fibronectin type 3 domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Epha7
    ortholog to murine Epha7
    Homologene
    FAMILY
  • TYR family of protein kinases
  • ephrin receptor subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to membrane
  • type I membrane protein
  • basic FUNCTION
  • may be mediating cellular adhesion or repulsion during embryonic development
  • acting as a receptor for members of the ephrin-A family
  • playing a key role in controlling the size of cerebral cortex by regulating cortical progenitor cell apoptosis
  • EFNA2 and EPHA7 as negative regulators of progenitor cell proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • EFNA1
  • EFNA2
  • EFNA3
  • EFNA4
  • EFNA5
  • PRKCABP
  • GRIP1
  • interacting with HOXA13 (HOXA13 directly regulates EPHA6 and EPHA7 in the developing GT (genital tubercle) and identifies the GT vascular endothelia as a novel site for HOXA13-dependent expression of EPHA6 and EPHA7)
  • DLX5 and MSX2 play potentially a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the EPHA5 and EPHA7 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal cancer, via aberrant 5'CpG island methylation
    tumoral       loss of function
    in follicular lymphoma (FL)
    tumoral     --over  
    expressed at a substantial level in most human lung cancers and the secreted form of EPHA7 mRNA was found in a fraction of primary lung cancer tissues
    tumoral     --over  
    correlates with adverse outcome in primary and recurrent glioblastoma multiforme
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    tumor suppressor with immediate therapeutic potential in follicular lymphoma
    ANIMAL & CELL MODELS