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FLASH GENE
Symbol EPHA6 contributors: mct - updated : 06-02-2012
HGNC name EPH receptor A6
HGNC id 19296
Location 3q11.2      Physical location : 96.533.424 - 97.467.786
Synonym name
  • EPH homology kinase 2
  • tyrosine-protein kinase receptor EHK-2
  • ephrin receptor EphA6
  • Synonym symbol(s) FLJ35246, DKFZp434C1418, EHK2, EPA6, PRO57066, UNQ6114
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 934.36 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3677 126.43 1130 - 2004 14726470
    13 - 1617 37.14 334 - 2004 14726470
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivemale systemtestis  predominantly Homo sapiens
     male systemprostate   
    Visualeyeretinamacula   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • in the macula of developing retina
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • ephrin receptor subfamily
  • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • in line with a number of other Eph receptors and their ephrin ligands, is potentially involved in neural circuits underlying aspects of learning and memory
  • FOXD1 downstream effector that sends temporal axons to the rostral colliculus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HOXA13 (HOXA13 directly regulates EPHA6 and EPHA7 in the developing GT (genital tubercle) and identifies the GT vascular endothelia as a novel site for HOXA13-dependent expression of EPHA6 and EPHA7)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS