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FLASH GENE
Symbol EPHA5 contributors: mct/npt - updated : 08-02-2012
HGNC name EPH receptor A5
HGNC id 3389
Location 4q13.1      Physical location : 66.185.281 - 66.535.653
Synonym name
  • TYRO4 protein tyrosine kinase
  • receptor protein-tyrosine kinase HEK7
  • ephrin type-A receptor 5 precursor
  • tyrosine-protein kinase receptor EHK-1
  • Synonym symbol(s) HEK7, CEK7, EHK1, TYRO4
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 345.86 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC285427 4q13.1 similar to Exocyst complex component Sec10 (hSec10) LOC132369 4q13.2 similar to FLJ10378 protein isoform 2 LOC253017 4q13.2 hypothetical protein LOC253017 LOC391657 4 similar to dipeptidylpeptidase III isoform 1; dipeptidylpeptidase III EPHA5 4q13.1 EphA5 CENPC1 4q13.2-q21.1 centromere protein C 1 BRDG1 4q13.1 centromere protein C 1 FLJ10808 4q13.3 hypothetical protein FLJ10808 LOC391658 4 similar to CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-ST) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3GalIA) (ST3O) (ST3GalA LOC391659 4 similar to hypothetical protein FLJ20397 GNRHR 4q21.2 gonadotropin-releasing hormone receptor HAT 4q13.3 airway trypsin-like protease LOC339967 4q13.3 hypothetical protein LOC339967 LOC339968 4q13.3 similar to RIKEN cDNA 9930032O22 gene LOC339970 4q13.3 similar to glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A LOC389208 4 similar to RIKEN cDNA 4732406D01 gene LOC391660 4 similar to RIKEN cDNA 9930019B18 gene DKFZp686L1818 4q13.3 hypothetical protein DKFZp686L1818 LOC391661 4 similar to UDP-glucuronosyltransferase YT521 4q13.3 splicing factor YT521-B
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3349 115 1037 - Wilkinson (2001)
    17 - 3283 - 1015 - Wilkinson (2001)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnervespinal nervesciatic  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SAM domain
  • two fibronectin type 3 domain
  • HOMOLOGY
    interspecies homolog to murine Epha5
    Homologene
    FAMILY
  • TYR family of protein kinases
  • ephrin receptor subfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be involved in the maintenance of the adult nervous system and contributing to glioma development
  • key player in controlling these cell movements in many tissues and at multiple stages of patterning
  • EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EFNA5 and EPHA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TIAM1 plays a role in clathrin-dependent endocytosis of EPHA8-EPHA5 complexes
  • EFNA5 interaction with the EPHA5 receptor following neuron-neuron contact during early development of hippocampus induces a complex program of synaptogenic events
  • DLX5 and MSX2 play potentially a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the EPHA5 and EPHA7 pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS