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FLASH GENE
Symbol EPHA4 contributors: mct/pgu - updated : 08-02-2016
HGNC name EPH receptor A4
HGNC id 3388
Location 2q36.1      Physical location : 222.282.748 - 222.437.010
Synonym name
  • ephrin type-A receptor 4 precursor
  • receptor protein-tyrosine kinase HEK8
  • tyrosine-protein kinase receptor SEK
  • Synonym symbol(s) HEK8, TYRO1, EPA4, SEK
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 154.26 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 6364 110 986 - 2004 12649481
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text expressed in the developing striatum, an area that is strictly avoided by migrating cortical interneurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SAM motif
  • two fibronectin type 3 domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • tyr protein kinase family
  • ephrin receptor subfamily
  • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be playing a role in a signal transduction process involved in hindbrain pattern formation
  • playing a role in local neuronal circuits that control walking
  • involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor
  • EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EPHA4/EFNAA3 signaling is potentially a critical mechanism for astrocytes to regulate synaptic function and plasticity
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between neuronal EPHA4 and glial EFNA3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function
  • mediates at least in part the repulsive effect of EFNA3 in the neurons from the medial ganglionic eminence
  • direct interaction between SIPA1L3 and EPHA4, building a functional platform for proper ocular development
  • novel role for SORL1 as a physiological and pathological EPHA4 modulator, which attenuates synaptotoxic EPHA4 activation and cognitive impairment associated with APP-induced neurodegeneration in Alzheimer disease
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease brains
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS