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FLASH GENE
Symbol EPHA3 contributors: mct/npt - updated : 08-07-2011
HGNC name EPH receptor A3
HGNC id 3387
Location 3p11.2      Physical location : 89.156.673 - 89.531.282
Synonym name
  • EPH-related tyrosine kinase receptor 3
  • eph-like tyrosine kinase 1
  • TYRO4 protein tyrosine kinase
  • Synonym symbol(s) ETK1, HEK, ETK, HEK4, TYRO4
    EC.number 2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 374.61 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389133 3 LOC389133 GBE1 3p12 glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) CYP51P1 3q12.1-q13.11 glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) LOC389135 3 similar to hypothetical protein FLJ11292 LOC253559 3p12.2 nectin-like protein 3 LOC51159 3p12.2 colon carcinoma related protein LOC389136 3 similar to vestigial-like 2 isoform 1; transcription cofactor vestigial-like 2 LOC285232 3p12.2 phosphoribosyl pyrophosphate amidotransferase pseudogene DKFZP564O123 3p12.1 DKFZP564O123 protein POU1F1 3p11 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) LOC285233 3p12.1 similar to keratin 8, type II cytoskeletal - human LOC200899 3p12.1 similar to protease (prosome, macropain) 26S subunit, ATPase 1 HTR1F 3p14.1-p13 5-hydroxytryptamine (serotonin) receptor 1F CGGBP1 3p12-p11.1 CGG triplet repeat binding protein 1 FLJ10997 3p12.1 hypothetical protein FLJ10997 MGC26717 3p12.1 hypothetical protein MGC26717 LOC344653 3p12.1 similar to ATP-binding cassette, sub-family F, member 2 isoform b; ABC-type transport protein; Iron inhibited ABC transporter 2 EPHA3 3p11.2 EphA3 PROS1 3p11 protein S (alpha) DKFZp761H079 3q11.2 hypothetical protein DKFZp761H079 LOC200895 3q11.2 hypothetical protein LOC200895 FLJ22609 3q11.2 hypothetical protein FLJ22609 LOC389137 3 similar to SVH-B LOC344620 3q11.2 similar to CG17293-PA LOC255025 3q11.2 hypothetical protein LOC255025
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 5837 110 983 - 2004 14697337
    7 - 2684 - 539 - 2004 14697337
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivefemale systemplacenta  highly
     male systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage some pre-B and T cell lines
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a vestigial Ig-l domain
  • a single cystein rich region
  • two FNIII domains in the extracellular region
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Tyr protein kinase family
  • ephrin receptor
  • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in short-range contact-mediated axonal guidance
  • key players in controlling these cell movements in many tissues and at multiple stages of patterning
  • suppresses motility through regulation of Rho GTPases in rhabdomyosarcoma cells
  • mediate processes involving cell-cell contact, including cellular adhesion or repulsion, developmental remodeling and neuronal mapping
  • EPHA3 and PROM1 may play an important role in the development and progression of colorectal tumours
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPH-related tyrosine kinase receptor binding ephrins A
  • EPHA3-PTPN1 interaction can occur directly at the plasma membrane
  • cell & other
    REGULATION
    induced by CD28 and IGF-1 and regulates cell adhesion
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in breast, lung, and pancreatic cancers
    tumoral     --other  
    not detected in normal peripheral T cells, in any subset of thymus-derived developing T cells, or in Hodgkin's lymphoma, but detected in a panel of T-cell lymphomas
    tumoral     --over  
    associated with lymphocytic leukaemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker useful indicators for clinical assessment of tumour biological behaviour and prognosis in patients with colorectal carcinoma
    Therapy target
    ANIMAL & CELL MODELS