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FLASH GENE
Symbol EPHA1 contributors: mct - updated : 25-03-2014
HGNC name EPH receptor A1
HGNC id 3385
Location 7q35      Physical location : 143.088.206 - 143.105.985
Synonym name
  • EPH-related tyrosine kinase receptor 1
  • tyrosine-protein kinase receptor EPH
  • erythropoietin-producing hepatoma receptor
    • Synonym symbol(s) EPHT1, EPHT, EPH
    EC.number 2.7.1.112/2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 17.82 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • ATF3 stimulated promoter activity of EPHA1
    • MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3369 - 976 - 2001 1151982
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single cysteine rich region
  • two FNIII domains in the extracellular region
  • C-terminal sterile alpha motif (SAM) domain is required and the ankyrin region of ILK is sufficient for the interaction between EPHA1 and ILK
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • Eph family
  • receptor tyrosine kinase, class VIII family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor tyrosine kinase
  • involved in short-range contact-mediated axonal guidance
  • EPHA1 signal facilitates IGF1-induced myogenesis by suppressing the RAS-ERK1/2 cascade through RASA1 in myoblast cell lines
  • may have roles in carcinogenesis and progression of prostate cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • regulates cell morphology and motility through the ILK-RHOA-ROCK pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP
    protein
  • binding of EPHA1 to fibronectin through its type I repeat played an essential role in the angiogenesis
  • interaction between EPHA1 and ILK
  • HIC1 is a direct transcriptional repressor of EPHA1, a cell surface ligand implicated in the pathogenesis of epithelial cancers
  • cooperation between SLIT2 and EPHA1 regulates a balance between the pro- and antiangiogenic functions of SLIT2
  • ADAM12 enhanced EPHA1 cleavage in response to TGFB1 in primary tumors
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)
    tumoral     --low  
    epigenetic silencing of EPHA1 expression in colorectal cancer is correlated with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    can be a potentially useful target for prognostic and therapeutic application
    ANIMAL & CELL MODELS