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FLASH GENE
Symbol EPHA1 contributors: mct - updated : 25-03-2014
HGNC name EPH receptor A1
HGNC id 3385
Location 7q35      Physical location : 143.088.206 - 143.105.985
Synonym name
  • EPH-related tyrosine kinase receptor 1
  • tyrosine-protein kinase receptor EPH
  • erythropoietin-producing hepatoma receptor
    • Synonym symbol(s) EPHT1, EPHT, EPH
    EC.number 2.7.1.112/2.7.10.1
    DNA
    TYPE functioning gene
    STRUCTURE 17.82 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • ATF3 stimulated promoter activity of EPHA1
    • MAPPING cloned Y linked   status confirmed
    Physical map
    EPHB6 7q33-q35 EphB6 TRPV6 7q33-q34 transient receptor potential cation channel, subfamily V, member 6 TRPV5 7q35 transient receptor potential cation channel, subfamily V, member 5 C7orf34 7q35 chromosome 7 open reading frame 34 KEL 7q33 Kell blood group LOC135924 7q35 similar to Olfactory receptor 9A2 LOC346517 7q35 similar to Olfactory receptor 6V1 sdolf 7q35 olfactory receptor sdolf PIP 7q34 prolactin-induced protein TAS2R39 7q35 taste receptor, type 2, member 39 TAS2R40 7q35 taste receptor, type 2, member 40 LOC51064 7q35 glutathione S-transferase subunit 13 homolog FLJ90586 7q35 hypothetical protein FLJ90586 CASP2 7q34-q35 caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2) LOC346521 7q35 similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) CLCN1 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) KIAA0773 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) LOC202775 7q35 hypothetical LOC202775 ZYX 7q34-q35 zyxin EPHA1 7q32-q34 EphA1 TAS2R62P 7q35 taste receptor, type 2, member 62 pseudogene TAS2R60 7q35 taste receptor, type 2, member 60 TAS2R41 7q35 taste receptor, type 2, member 41 LOC392132 7 similar to olfactory receptor MOR257-1 LOC392133 7 similar to seven transmembrane helix receptor LOC392134 7 similar to 60S ribosomal protein L26 LOC392135 7 similar to Multifunctional protein ADE2 FLJ40722 7q35 hypothetical protein FLJ40722 MGC41943 7q35 hypothetical protein MGC41943 LOC392136 7 similar to Multifunctional protein ADE2 LOC392137 7 similar to 60S ribosomal protein L26 KIAA0738 7q35 similar to 60S ribosomal protein L26
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3369 - 976 - 2001 1151982
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single cysteine rich region
  • two FNIII domains in the extracellular region
  • C-terminal sterile alpha motif (SAM) domain is required and the ankyrin region of ILK is sufficient for the interaction between EPHA1 and ILK
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • Eph family
  • receptor tyrosine kinase, class VIII family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • receptor tyrosine kinase
  • involved in short-range contact-mediated axonal guidance
  • EPHA1 signal facilitates IGF1-induced myogenesis by suppressing the RAS-ERK1/2 cascade through RASA1 in myoblast cell lines
  • may have roles in carcinogenesis and progression of prostate cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • regulates cell morphology and motility through the ILK-RHOA-ROCK pathway
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP
    protein
  • binding of EPHA1 to fibronectin through its type I repeat played an essential role in the angiogenesis
  • interaction between EPHA1 and ILK
  • HIC1 is a direct transcriptional repressor of EPHA1, a cell surface ligand implicated in the pathogenesis of epithelial cancers
  • cooperation between SLIT2 and EPHA1 regulates a balance between the pro- and antiangiogenic functions of SLIT2
  • ADAM12 enhanced EPHA1 cleavage in response to TGFB1 in primary tumors
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma (HCC)
    tumoral     --low  
    epigenetic silencing of EPHA1 expression in colorectal cancer is correlated with poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    can be a potentially useful target for prognostic and therapeutic application
    ANIMAL & CELL MODELS