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FLASH GENE
Symbol EPC1 contributors: mct/npt - updated : 16-12-2009
HGNC name enhancer of polycomb homolog 1, (Drosophila)
HGNC id 19876
Location 10p11.22      Physical location : 32.557.858 - 32.636.113
Synonym name enhancer of polycomb 1
Synonym symbol(s) Epl1, DKFZp781P2312
DNA
TYPE functioning gene
STRUCTURE 78.26 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC347806 10p12.1 similar to hypothetical protein FLJ10817 LOC340913 10p12.1 similar to breast cancer antigen NY-BR-1 LOC338617 10p12.1 similar to HSPC132 FLJ44037 10p12.1 FLJ44037 protein RAB18 10p12.1 RAB18, member RAS oncogene family C10orf48 10p12.1 chromosome 10 open reading frame 48 FLJ10817 MRPS21P5 10p12.1 mitochondrial ribosomal protein S21 pseudogene 5 FLJ32798 LOC389945 10 similar to zinc finger protein 12 LOC340917 10p12.1 similar to laminin-binding protein WAC 10p12.1-p11.2 similar to laminin-binding protein NMA 10p12.3-p11.2 similar to laminin-binding protein MGC45541 10p12.1 hypothetical protein MGC45541 LOC256457 10p12.1 similar to 60S ribosomal protein L21 MGC33408 10p12.1 similar to lysozyme C-1 (1,4-beta-N-acylmuramidase C, EC 3.2.1.17) LOC387647 10 hypothetical gene supported by BC014163 SVIL 10p11.2 supervillin bA192N10.2 10q11.1 cell division control protein CKS1 pseudogene KIAA1462 10p12.1 KIAA1462 FLJ10486 10p12.1 hypothetical protein FLJ10486 LOC389946 10 similar to G1/S-specific cyclin D3 MAP3K8 10p11.2 mitogen-activated protein kinase kinase kinase 8 LOC119180 10p11.23 lysozyme 2 LOC143110 10p11.23 similar to supervillin isoform 2; membrane-associated F-actin binding protein p205; archvillin LOC387648 10 similar to supervillin isoform 2; membrane-associated F-actin binding protein p205; archvillin LOC220929 10p11.23 hypothetical protein LOC220929 TCF8 10p11.2 transcription factor 8 (represses interleukin 2 expression) LOC387649 10 LOC387649 ARHGAP12 10pter-cen Rho GTPase activating protein 12 KIF5B 10p11.2 kinesin family member 5B LOC387650 10 hypothetical gene supported by BC000689; NM_021130; NR_000030 EPC1 10p11 enhancer of polycomb homolog 1, (Drosophila) FLJ32762 FLJ13031 ITGB1 10p11.2 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) LOC340933 10p11.23 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) NRP1 10p12 neuropilin 1 PARD3 10p11.23 par-3 partitioning defective 3 homolog (C. elegans) CUL2 10p11.2-p11.1 cullin 2 CREM 10p12.1-p11.1 cAMP responsive element modulator C10orf9 10p11.22 chromosome 10 open reading frame 9 CX40.1 10p11.22 connexin40.1 FZD8 10p11.22 frizzled homolog 8 (Drosophila) LOC389947 10 similar to ribosomal protein L7 LOC387651 10 similar to Pre-B cell enhancing factor precursor LOC389948 10 similar to MAP kinase-interacting serine/threonine kinase 1; MAP kinase interacting kinase 1 NY-BR-1 10p11.21 breast cancer antigen NY-BR-1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2913 - 836 - Taniwaki (2009)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text highly expressed in the embryonic heart (Kee 2007)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an activating EPcA domain
  • a repressive C terminal region
  • HOMOLOGY
    interspecies homolog to Drosophila enhancer of polycomb
    Homologene
    FAMILY
  • enhancer of polycomb family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus,nucleoplasm
    text colocolizing with RFP
    basic FUNCTION
  • both repressive and transactivating transcriptional activities
  • plays a role in the initiation of skeletal muscle differentiation, and its interaction with HOPX is required for the full activity (Kee 2007)
  • recruits both serum response factor (SRF) and EP300 to induce skeletal muscle differentiation (Kim 2009)
  • required for skeletal muscle differentiation by recruiting both SRF and EP300 to the serum response element of muscle-specific gene promoters (Kim 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with E2F6 (E2F6-EPC1 complex) (E2F6-EPC1 interacts with EZH2 and may regulate genes required for cell cycle progression) (Attwooll 2005)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coiled-coil domain of RFP
  • complex (E2F6-EPC1) interacts with EZH2 and may regulate genes required for cell cycle progression
  • interacted physically with SRF
  • directly bound to EP300 in myoblast cells (Kim 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion with ASXL2 (EPC1/ASXL2 enhanced cell growth in T-leukemia cells) (Nakahata 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS