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FLASH GENE
Symbol EPB41L5 contributors: mct/npt/pgu - updated : 16-02-2010
HGNC name erythrocyte membrane protein band 4.1 like 5
HGNC id 19819
Location 2q14.2      Physical location : 120.770.603 - 120.936.701
Synonym symbol(s) KIAA1548, BE37, YF48, FLJ12957, YMO1, Lulu1
DNA
TYPE functioning gene
STRUCTURE 166.03 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 6567 81.7 733 - 2007 17920587
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselsaorta  highly
Endocrinepancreas    
Nervousbrain    
 spinal cord   highly
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines pancreatic cancer cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FERM domain, involved in binding to the HOOK domain of MPP5, a previously identified interactor of Crumbs
  • one band 4.1 like domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the mammalian CRB-MPP5 polarity complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the intracellular domains of all three Crumbs homologs through its FERM domain
  • binds to paxillin through its C terminus, enhancing integrin/paxillin association, thereby stimulating focal adhesion formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS