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FLASH GENE
Symbol EPB41L4B contributors: mct - updated : 31-10-2015
HGNC name erythrocyte membrane protein band 4.1 like 4B
HGNC id 19818
Location 9q31.3      Physical location : 111.934.253 - 112.083.021
Synonym name
  • FERM-containing protein
  • FERM-containing protein CG1
  • Synonym symbol(s) CG1, EHM2, FLJ21596, DKFZp761N1814, Lulu2
    DNA
    TYPE functioning gene
    STRUCTURE 148.77 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392379 9 similar to constitutive photomorphogenic protein FLJ13385 9q32 hypothetical protein FLJ13385 ZNF462 9q32 zinc finger protein 462 LOC389782 9 LOC389782 RAD23B 9q31.2 RAD23 homolog B (S. cerevisiae) KLF4 9q31 Kruppel-like factor 4 (gut) LOC392380 9 similar to peptidylprolyl isomerase A (cyclophilin A) LOC392381 9 similar to large subunit ribosomal protein L36a LOC392382 9 similar to ribosomal protein L31 LOC347292 9q32 similar to ribosomal protein L36; 60S ribosomal protein L36 IKBKAP 9q31 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein ACTL7B 9q31 actin-like 7B ACTL7A 9q31 actin-like 7A FLJ20457 9q32 hypothetical protein FLJ20457 CTNNAL1 9q31.2 catenin (cadherin-associated protein), alpha-like 1 C9orf5 9q31 chromosome 9 open reading frame 5 EPB41L4B 9q22.1-q22.3 erythrocyte membrane protein band 4.1 like 4B FLJ21596 9q32 hypothetical protein FLJ21596 PTPN3 9q31.2 protein tyrosine phosphatase, non-receptor type 3 LOC347295 9q32 similar to DNA-binding protein B LOC389783 9 LOC389783 AKAP2 9q31-q33 a kinase (PRKA) anchor protein 2 PALM2 9q31-q33 paralemmin 2 TXN 9q31 thioredoxin LOC255220 9q32 similar to RIKEN cDNA 4930429J24 MUSK 9q31.3-q32 muscle, skeletal, receptor tyrosine kinase EDG2 9q31.3-q32 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 OR2K2 9q32 olfactory receptor, family 2, subfamily K, member 2 OR2AR1P 3p24.1 olfactory receptor, family 2, subfamily AR, member 1 pseudogene KIAA0368 9q22.3-q32 olfactory receptor, family 2, subfamily AR, member 1 pseudogene ZNF483 9 zinc finger protein 483
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 5578 - 900 - 2006 1695012
    16 - 3783 - 518 - 2006 1695012
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver    
    Reproductivemale systemprostate  highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one FERM domain (325 AA) controlling cytoskeletal function in differentiating cells
  • HOMOLOGY
    interspecies homolog to murine Epb41l4b
    homolog to Drosophila melanogaster Yurt
    intraspecies homolog to NBL4
    Homologene
    FAMILY
  • NF2/ERM/4.1 superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    text
  • localized along apical cell-cell boundaries
  • basic FUNCTION
  • may promote the invasive ability of breast cancer cells via regulation of matrix metalloproteinase 9 (MMP9)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with and activates ARHGEF18, a Rho-specific guanine nucleotide exchanging factor (GEF), at apical cell-cell junctions
  • CRB3-dependent changes in endocytic trafficking were also dependent on EPB41L4B
  • cell & other
    REGULATION
    Other regulated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    were correlated with breast cancer progression, metastasis, and poor prognosis (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS