Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EOGT contributors: mct - updated : 08-01-2014
HGNC name EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
HGNC id 28526
Corresponding disease
AOS4 Adams-Oliver syndrome 4
Location 3p14.1      Physical location : -
Synonym name
  • AER61 glycosyltransferase
  • chromosome 3 open reading frame 64
  • Synonym symbol(s) FLJ13078, MGC34132, AER61, FLJ33770, FLJ41219, C3orf64, EOGT1
    EC.number 2.4.1.255
    DNA
    TYPE functioning gene
    STRUCTURE 38.41 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 4152 - 443 - 2011 22158438
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Hearing/Equilibriumearinnercochlea  
    Reproductivefemale systemuterus   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to highly homologous to POMGNT2
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localizes to the lumen of the endoplasmic reticulum
    basic FUNCTION
  • transferase activity
  • responsible for extracellular O-GlcNAcylation
  • encodes EGF domain O-GlcNAc transferase and potentially, O-GlcNAcylation reaction in the secretory pathway is a fundamental biochemical process conserved through evolution
  • involved in the O-GlcNAcylation (attachment of O-GlcNAc to serine and threonine residues) of a subset of extracellular EGF-domain-containing proteins (
  • may regulate protein functions by O-GlcNAc modification of their EGF repeats, and cellular metabolism by affecting pyrimidine synthesis and catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transfers GlcNAc to epidermal growth factor-like domains in an OGT-independent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AOS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS