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FLASH GENE
Symbol ENY2 contributors: mct/npt - updated : 26-10-2016
HGNC name enhancer of yellow 2 homolog (Drosophila)
HGNC id 24449
Location 8q23.1      Physical location : 110.346.551 - 110.358.188
Synonym symbol(s) DC6, e(y)2, FLJ20480, SUS1
DNA
TYPE functioning gene
STRUCTURE 11.64 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2948 - 101 - 2001 11438676
5 - 2876 - 96 - 2001 11438676
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestivemouthtongue  moderately
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuterus  moderately
 male systemtestis  highly
Skin/Tegumentskin   highly
Urinarykidney   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ENY2 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • involved in the regulation of transcription
  • with USP22, and ATXN7L3, are required as cofactors for the full transcriptional activity by nuclear receptors (Zhao 2008)
  • is a multifunctional protein important for transcription activation and mRNA export, being a component of SAGA/TFTC complex
  • PCID2 but not ENY2 is also involved in protein export
  • ATXN7L3 and ENY2 orchestrate activities of multiple deubiquitinating enzymes and imbalances in these activities likely potentiate human diseases including cancer
  • ATXN7L3 and ENY2, are necessary for deubiquitinase (DUB) activity towards histone H2Bub1 and other substrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MCM3AP is required to recruit ENY2 to nuclear pore complexes (NPCs), but ENY2 is not necessary to recruit MCM3AP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS