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FLASH GENE
Symbol ENTPD5 contributors: mct - updated : 06-07-2011
HGNC name ectonucleoside triphosphate diphosphohydrolase 5
HGNC id 3367
Location 14q24.3      Physical location : 74.433.182 - 74.486.026
Synonym name
  • CD39-like 4, homolog to the lymphoid cell activation antigen CD39,and to E type ecto ATPase
  • proto-oncogene CPH
  • Synonym symbol(s) CD39L4 , ENP5, PCPH, NTPDase-5, ER-UDPase, MGC163357, MGC163359
    EC.number 3.6.1.6
    DNA
    TYPE functioning gene
    STRUCTURE 52.79 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • promoter region of ENTPD5 is negatively regulated by the FOXO family of transcription factors, which upon phosphorylation by AKT1, are displaced from the nucleus into the cytoplasm
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2064 47.4 428 - 2001 11713596
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon predominantly
     liver   predominantly
    Nervousbrain    
    Reproductivemale systemtestis  predominantly
    Respiratorylung    
    Urinarykidney   predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one transmembrane segment at the N terminus
  • four apyrase conserved regions (ACR) in the N terminal region
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Mntpase
    intraspecies homolog to lymphoid cell activation antigen CD39
    homolog to PCPH proto-oncogene
    Homologene
    FAMILY
  • lymphoid activation antigen CD39 protein family
  • ENTPD enzyme family
  • CATEGORY enzyme , antigen , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • promoting reglycosylation reactions involved in glycoprotein folding and quality control in the endoplasmic reticulum
  • involved in the regulation of eukaryotic cell proliferation and stress response
  • its deregulation may participate in neoplastic progression
  • soluble enzyme that hydrolyzes purine nucleoside diphosphates
  • hydrolyzes UDP to UMP to promote protein N-glycosylation and folding in ER
  • integral part of the PI3K/PTEN regulatory loop, and critical link in the PI3K/PTEN pathway that promotes cell growth and survival, a pathway that is often activated in cancer cells
  • the only intracellular ENTPDase that is transcriptionally upregulated in PTEN null cells
  • critical player in causing the Warburg effect, i.e., elevated lactate production under aerobic conditions, in these PTEN null cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
  • Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human prostatic intraepithelial neoplasia , detectable in benign prostatic hyperplasia, highly expressed in prostatic intraepithelial neoplasia, and remaining at high levels in prostate carcinoma
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • good early molecular marker for testicular neoplasms, and immunodetection of truncated ENTPD5 polypeptides may be a useful diagnostic tool for testicular germ cell tumors
  • altered ENTPD5 polypeptides by Western analysis potentially can be applied to the early identification of laryngeal squamous cell carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for anticancer therapy
    cancer  
    developing ENTPD5 inhibitors for cancer therapy may be a worthwhile pursuit
    ANIMAL & CELL MODELS
  • nactivation of Entpd5 in mice (Entpd5(-/-)) resulted in 2 major histopathologic lesions: hepatopathy and aspermia