basic FUNCTION
| promoting reglycosylation reactions involved in glycoprotein folding and quality control in the endoplasmic reticulum |
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involved in the regulation of eukaryotic cell proliferation and stress response |
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its deregulation may participate in neoplastic progression |
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soluble enzyme that hydrolyzes purine nucleoside diphosphates |
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hydrolyzes UDP to UMP to promote protein N-glycosylation and folding in ER |
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integral part of the PI3K/PTEN regulatory loop, and critical link in the PI3K/PTEN pathway that promotes cell growth and survival, a pathway that is often activated in cancer cells |
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the only intracellular ENTPDase that is transcriptionally upregulated in PTEN null cells |
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critical player in causing the Warburg effect, i.e., elevated lactate production under aerobic conditions, in these PTEN null cells |