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FLASH GENE
Symbol ENTPD2 contributors: mct/npt - updated : 03-12-2014
HGNC name ectonucleoside triphosphate diphosphohydrolase 2
HGNC id 3364
Location 9q34.3      Physical location : 139.942.552 - 139.948.505
Synonym name
  • CD39-like 1, homolog to the lymphoid cell activation antigen CD39, and to E type ecto ATPase
  • CD39 antigen-like 1
  • ecto-ATPase
    • Synonym symbol(s) CD39L1, NTPDase-2
    EC.number 3.6.1.3
    DNA
    TYPE functioning gene
    STRUCTURE 5.94 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2156 53 495 - 2005 16101300
    9 - 2087 - 472 - 2005 16101300
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Nervousbrainlimbic systemhippocampusdentate gyrushighly Homo sapiensFetal
     nerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two potential transmembrane segments at the N and C termini
  • four apyrase conserved regions (ACR) in the N terminal region
  • conserved motifs including five apyrase conserved regions (ACRs)
  • four conserved regions (CRs) as well as conserved lysine and arginine residues that are also present in other cell surface E-NTPDases
  • six potential N-linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to lymphoid cell activation antigen CD39
    Homologene
    FAMILY
  • GDA1/CD39 NTPase family
    • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • ecto-nucleosidases that hydrolyze 5'-triphosphates
  • by regulating angiogenesis and inflammation, seems to play an important role in tumor progression
  • expressed at a much lower level than ENTPD5, but was also elevated in PTEN null cells
  • cellular homeostasis and fibrotic response involve the integration of signaling that is pro-fibrotic by ATP and anti-fibrotic by adenosine and that is regulated by ENTPD1 and ENTPD2
  • ectoenzyme that hydrolyzes extracellular nucleoside di- and triphosphates
  • has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, thereby acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation and expansion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • Mg2+
    • protein
  • IL6 markedly downregulated ENTPD2 mRNA expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in biliary cirrhosis
    tumoral     --over  
    in hepatoma
    constitutional   deletion    
    results in decreased neural responses to taste stimuli
    constitutional     --over  
    ENTPD2 overexpression modulated pro-inflammatory cytokine production and platelet reactivity
    tumoral     --over  
    in gliomas promotes systemic inflammation and pulmonary injury
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • brains of Entpd2 null mice revealed increased progenitor cell proliferation in both the subventricular zone (SVZ) and the subgranular layer (SGL)