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FLASH GENE
Symbol ENPP6 contributors: - updated : 02-03-2007
HGNC name ectonucleotide pyrophosphatase/phosphodiesterase 6
HGNC id 23409
Location 4q35.1      Physical location : 185.009.859 - 185.139.114
Synonym symbol(s) MGC33971, NPP6
EC.number 3.6.1.9
DNA
TYPE functioning gene
STRUCTURE 129.00 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
ODZ3 4q35.1 odd Oz/Ten-m homolog 3 DCTD 4q35.1 dCMP deaminase FLJ30277 4q35.1 hypothetical protein FLJ30277 BOMB 4q35.1 BH3-only member B protein CLDN22 4pter-qter claudin 22 LOC391721 4 similar to Claudin-22 LOC389245 4 LOC389245 CARF 4q35.1 LOC389245 LOC389246 4 similar to vesicle-associated soluble NSF attachment protein receptor (v-SN; vesicle-associated soluble NSF attachment protein receptor (v-SNARE; homolog of S. cerevisiae VTI1) LOC389247 4 hypothetical gene supported by BC038563 ING1L 4q35.1 inhibitor of growth family, member 1-like MGC10198 4q35.1 hypothetical protein MGC10198 FLJ12716 4q35.1 FLJ12716 protein DKFZp762K222 4q35.1 hypothetical protein DKFZp762K222 ENPP6 4q35.1 ectonucleotide pyrophosphatase/phosphodiesterase 6 LOC391722 4 similar to myosin:SUBUNIT=regulatory light chain MGC24125 4q35.1 hypothetical protein MGC24125 IRF2 4q35.1 interferon regulatory factor 2 CASP3 4q35 caspase 3, apoptosis-related cysteine protease FLJ33167 4q35.1 hypothetical protein FLJ33167 KLIP1 4q35.1 KSHV latent nuclear antigen interacting protein 1 FACL2 4q34-q35 fatty-acid-Coenzyme A ligase, long-chain 2 LOC285435 4q35.1 hypothetical LOC285435 LOC391723 4 similar to Heslike SLC25A4 4q35 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 KIAA1430 4q35.1 KIAA1430 protein SNX25 4q35.1 sorting nexin 25 DKFZp761O0113 4q35.1 hypothetical protein DKFZp761O0113 Lrp2bp 4q35.1 low density lipoprotein receptor-related protein binding protein FLJ11200 4q35.1 hypothetical protein FLJ11200 MGC33607 4q35.1 hypothetical protein MGC33607 ALP LOC391724 4 similar to glycine-rich protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach    
Nervousnervecranial nerve   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an NPP domain with significant homology to NPP4, NPP5, and NPP7/alkaline sphingomyelinase
HOMOLOGY
interspecies homolog to murine Enpp6
Homologene
FAMILY ENPP family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • choline-specific glycerophosphodiester phosphodiesterase
  • hydrolyzes LPC to form monoacylglycerol and phosphorylcholin
  • having a specific role through the hydrolysis of polyunsaturated lysophosphatidylcholine, glycerophosphorylcholine, or sphingosylphosphorylcholine in kidney and brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    nucleotide metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS