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FLASH GENE
Symbol ENPP4 contributors: KTN/npt - updated : 14/10/2008
HGNC name ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function)
HGNC id 3359
Location 6p12.3      Physical location : 46.097.700 - 46.114.435
Synonym symbol(s) NPP4, KIAA0879, NPP-4, E-NPP4
EC.number 3.1.-.-
DNA
TYPE functioning gene
STRUCTURE 16.37 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4697 51.5 453 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   moderately
Endocrineadrenal gland   moderately
 parathyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrain   highly
Respiratoryrespiratory tracttrachea  moderately
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 15 aa signal peptide
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog ENPP4 (89.8 pc)
    homolog to chimpanzee ENPP4 (99.8 pc)
    homolog to cow ENPP4 (87 pc)
    homolog to rattus Enpp4 (82.7 pc)
    homolog to murine Enpp4 (82.5 pc)
    Homologene
    FAMILY
  • ENPP family
  • nucleotide pyrophosphatase/phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    text single-pass type I membrane protein
    basic FUNCTION
  • acting as an hydrolase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS