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FLASH GENE
Symbol ENPP3 contributors: mct - updated : 29-11-2016
HGNC name ectonucleotide pyrophosphatase/phosphodiesterase 3
HGNC id 3358
Location 6q23.2      Physical location : 131.958.441 - 132.068.549
Synonym name
  • phosphodiesterase I/nucleotide pyrophosphatase 3
  • CD203c antigen
  • alkaline phosphodiesterase I
  • nucleotide pyrophosphatase
  • Synonym symbol(s) PDIB, PDNP3, PD-IBETA, gp130RB13-6, B10, CD203c
    EC.number 3.1.4.1, 3.6.1.9
    DNA
    TYPE functioning gene
    STRUCTURE 110.17 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3180 100 875 - Yano (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Lymphoid/Immunethymus   highly
    Nervousbrain     Rattus norvegicus
    Reproductivefemale systemuterus   
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • nucleotide pyrophosphatase/phosphodiesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • type II transmembrane protein
  • folded in the endoplasmic reticulum and then transported to the Golgi apparatus, where the catalytic domain of ENPP3 faces the lumen and would be predicted to catalyze the hydrolysis of nucleotide sugars
  • basic FUNCTION
  • phosphodiesterase I, beta nucleotide pyrophosphatase
  • involved in hydrolysis of extracellular nucleotides
  • involved in the infiltration of neoplastic bile duct carcinoma and is possible to be a tumor marker
  • has an extracellular role in modulating nucleotide-mediated signal transduction, a process that is known as purinergic signaling
  • basophil cell surface marker used to diagnose and monitor various allergic diseases
  • marked differences in the signaling requirements for expression of ENPP3 and ITGAM versus CD63 expression and histamine release in human basophils
  • is an inhibitor for MGAT5B, which catalyzes the hydrolysis of the nucleotide sugar donor substrate UDP-GlcNAc
  • important link of ENPP3 to the regulatory system for dictating the level of intracellular nucleotide sugars
  • plays likely a role in the glial cell differentiation process
  • has an intracellular function in which it plays a role in modulating the level of intracellular nucleotide sugars, possibly through its catalytic activity
  • nucleotide-converting ectoenzymes, such as ENTPD1, ENTPD7, and ENPP3, inhibit ATP-dependent immune responses by hydrolyzing ATP, thereby contributing to immune response regulation
  • ATP-hydrolyzing ectoenzymes ENPP3 has a nonnegligible role in the regulation of basophil- and mast cell-mediated allergic responses
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a regulator of glycosyltransferase activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in asthma exacerbation, increased expression of ENPP3 on basophils that decreased significantly during remission
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • basophil expression levels might therefore be used to monitor asthma in patients
  • Therapy target
    ANIMAL & CELL MODELS