lowest expression levels both in the central nervous system and peripheral tissues among the three isoforms
Narita, Kawagoe, Giganti (2008)
156-bp insert coding for 52 amino acids in the central domain
25
splicing
3120
99
863
high expression were detected in peripheral tissues, whereas lower expression levels were observed in the central nervous system, particularly expressed in adipocytes and in retina
Narita, Kawagoe, Giganti (2008)
-
-
-
-
889
highly detected in total brain, and also particularly expressed in adipocytes and in retina
Giganti (2008)
lacks the same 52-amino acid insertion found in melanoma autotaxin but contains an additional 25 residues in the C-terminal third of the protein
EXPRESSION
Type
widely
constitutive of
expressed in
(based on citations)
organ(s)
System
Organ level 1
Organ level 2
Organ level 3
Organ level 4
Level
Pubmed
Species
Stage
Rna symbol
Hearing/Equilibrium
ear
highly
Nervous
brain
specific
nerve
highly
Respiratory
lung
Urinary
kidney
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
pregnancy
Text
placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a short N-terminal intracellular domain involved in the targeting to the plasma membrane
a single transmembrane domain
a large extracellular domain encompassing two consecutive somatomedin-B-like domains