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FLASH GENE
Symbol ENPEP contributors: mct/np - updated : 01-04-2008
HGNC name glutamyl aminopeptidase (aminopeptidase A)
HGNC id 3355
Location 4q25      Physical location : 111.397.228 - 111.484.491
Synonym name
  • aminopeptidase A
  • differentiation antigen gp160
  • CD249 antigen
  • brain aminopeptidase A
  • Synonym symbol(s) APA, EAP, CD249, gp160
    EC.number 3.4.11.7
    DNA
    TYPE functioning gene
    STRUCTURE 87.00 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D4S1236 - ENPEP - D4S262 - D4S953 - D4S474 - IF - qter
    Authors Li (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 5004 109.3 957 - Engenheiro (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbraindiencephalonhypothalamus predominantly Homo sapiens
     brainforebraincerebral cortex highly Homo sapiens
     brainhindbrainmedulla oblongata highly Homo sapiens
     plexus choroid   predominantly Homo sapiens
    Urinarykidneynephronrenal capsuleglomerulushighly
     kidneytubuleconvoluted tubuleproximal tubulehighly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • large extracellular domain
  • a zinc binding motif typical of zinc dependent metallohydrolase
  • HOMOLOGY
    interspecies homolog to murine B-lymphocyte differentiation antigen BP-1/6C3
    Homologene
    FAMILY
  • peptidase M1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text integral type 2 membrane protein
    basic FUNCTION
  • cleaves aspartic and glutamic acidic residues from the N-terminus of a number of protein substrates that includes angiotensin II
  • implicating in the degradation of angiotensinogen II to angiotensinogen III in the brain and the kidney
  • integral component of the brain renin angiotensin system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to focal and segmental glomerulosclerosis (FSGS)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be clinically tested as an additional therapy for the treatment of certain forms of hypertension
    ANIMAL & CELL MODELS