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FLASH GENE

Symbol

ENOX2

contributors: mct - updated : 19-10-2016

HGNC name	ecto-NOX disulfide-thiol exchanger 2
HGNC id	2259

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq26.1      Physical location : 129.757.358 - 130.037.208
Genatlas name	ecto-nicotinamide adenine dinucleotide oxidase di-sulfide-thiol exchanger 2
Synonym name	tumor-associated hydroquinone (NADH) oxidase tNOX
	cytosolic ovarian carcinoma antigen 1
	APK1 antigen
	protein disulfide-thiol oxidoreductase
	hydroquinone [NADH] oxidase
Synonym symbol(s)	APK1, tNOX, COVA1

DNA

TYPE	functioning gene
STRUCTURE	280.99 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - DXS1047 - ENOX2 - DXS8072 - DXS8098 - DXS8041 - DXS984 - DXS998 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006375 15 - 4180 NP_006366 - 581 - 2010 20922471 NM_182314 16 - 4269 NP_872114 70 610 - 2010 20922471 NM_001281736 14 - 4035 NP_001268665 - 581 - 2010 20922471

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive liver       highly Homo sapiens Respiratory lung         Homo sapiens Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines	ovarian carcinoma cells expressing the surface glycoprotein CAK1 and gastric tumor cells
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three potential N-linked glycosylation sites
	multiple potential phosphorylation sites
	C-terminal portion corresponding to the processed plasma membrane-associated form include quinone (capsaicin), copper and adenine nucleotide binding domains
	two cysteines essential for catalytic activity

conjugated

GlycoP , MetalloP

HOMOLOGY

interspecies

ortholog to murine Cova1

Homologene

FAMILY

ENOX family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, but is absent from the surface of noncancer cells and from sera from healthy individuals
	contributing to the enlargement phase of cell growth
	growth-related protein expressed in transformed cells
	is present in the serum of cancer patients several years before the clinical symptoms of the tumor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

recognized by monoclonal antibody Mab-KI

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor, nucleotide,
	quinone (capsaicin)
	bound copper emerges as having an essential role in ENOX2 both for enzymatic activity and for the structural changes that underly the periodic alternations in activity that define the time-keeping cycle of the protein
	ATP

protein	HNRNPF directs formation of the exon 4 minus variant of ENOX2
	capsaicin inhibits the growth of bladder cancer cells by inhibiting ENOX2 and SIRT1 and thereby reducing proliferation, attenuating migration, and prolonging cell cycle progression

cell & other

REGULATION

Phosphorylated by

PRKCD, and phosphorylation of serine-504 by PRKCD modulates the biological function of ENOX2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     its inhibition is potentially a hope of improving cancer therapy

ANIMAL & CELL MODELS