Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ENOX1 contributors: mct/npt - updated : 27-10-2017
HGNC name ecto-NOX disulfide-thiol exchanger 1
HGNC id 25474
Location 13q14.11      Physical location : 43.787.679 - 44.361.106
Synonym name
  • candidate growth-related and time keeping constitutive hydroquinone
  • [NADH] oxidase
  • cell proliferation-inducing gene 38 protein
  • constitutive Ecto-NOX
  • proliferation-inducing protein 38
  • Synonym symbol(s) FLJ10094, PIG38, CNOX, cCNOX, bA64J21.1
    DNA
    TYPE functioning gene
    STRUCTURE 573.46 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3047 73.2 643 - 2005 15882838
    17 - 2706 73.2 643 - 2005 15882838
    17 - 3021 - 643 - 2005 15882838
    - - 3258 - 678 - 2005 15882838
    - - 3461 - 643 - 2005 15882838
    - - 3336 - 643 - 2005 15882838
    - - 3511 - 643 - 2005 15882838
    - - 3269 - 643 - 2005 15882838
    - - 3454 - 643 - 2005 15882838
    - - 3402 - 643 - 2005 15882838
    - - 3269 - 604 - 2005 15882838
    - - 3258 - 604 - 2005 15882838
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • ENOX family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • involved in plasma membrane transport pathways
  • exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity
  • conserved NADH oxidase that helps to regulate intracellular nicotinamide adenine dinucleotide levels in many cell types, including endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to familial autoimmune myasthenia
    Variant & Polymorphism other
  • variant in ENOX1 may contribute to the familial autoimmune myasthenia
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    represents an antiangiogenic druggable target
    cancer  
    ENOX1 represents a potential cancer therapy target, one that combines molecular targeting with cytotoxic sensitization
    ANIMAL & CELL MODELS