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FLASH GENE
Symbol ENOSF1 contributors: mct - updated : 02-11-2022
HGNC name enolase superfamily member 1
HGNC id 30365
Location 18p11.32      Physical location : 672.543 - 712.662
Synonym name
  • rTS beta protein
  • transcription unit convergent and overlapping TYMS
  • cDNA FLJ76087, highly similar to Homo sapiens enolase superfamily
    • member 1
    Synonym symbol(s) RTS, HSRTSBETA, TYMSAS, RTS beta, RTYMS
    EC.number 4.2.1.68
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping, gene in gene, opposite orientation
    text
  • ENOSF1 partially overlaps TYMS on chromosome 18 and is transcribed in the opposite direction to TYMS
    • STRUCTURE 49.65 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map see TYMS
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5362 49 443 - 2005 16162288
    15 - 5464 - 477 - 2005 16162288
    14 - 5364 - 262 - 2005 16162288
    15 - 5246 - 361 - 2005 16162288
    15 - 5320 - 429 - 2005 16162288
    16 - 5506 - 491 - 2005 16162288
    13 - 5275 - 414 - 2005 16162288
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines wide variety of cell lines,overexpressed in a 5-fluorocuro-cil-resistant cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • enolase superfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • having a catalytic activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TYMS differentially influencing cell sensibility to TYMS inhibitors
  • ENOSF1 modify TYMS expression at the RNA level by acting as an antisense molecule to TYMS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    digenic germline variants in both TYMS and ENOSF1 can generate disease features of dyskeratosis congenita
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • peptide regions of SERPINA1 and ENOSF1 expression are potential serum biomarkers for gastric cancer
    • Therapy target
    ANIMAL & CELL MODELS