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FLASH GENE
Symbol ENAH contributors: npt/mct/pgu - updated : 24-02-2009
HGNC name enabled homolog (Drosophila)
HGNC id 18271
Location 1q42.12      Physical location : 225.674.533 - 225.840.845
Synonym name
  • ortholog of mouse derived proline rich protein 1
  • enabled homolog
  • mammalian enabled
  • Synonym symbol(s) NDPP1, FLJ10773, MENA, ENA
    DNA
    TYPE functioning gene
    STRUCTURE 166.31 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D1S2550 - D1S2763 - ENAH - D1S439 - D1S525 - qter
    Physical map
    LOC388743 1 similar to calpain 8 CAPN2 1q41-q42 calpain 2, (m/II) large subunit TP53BP2 1q42.1 tumor protein p53 binding protein, 2 LOC391167 1 similar to prohibitin LOC343354 1q42.12 similar to beta actin LOC388744 1 similar to bA476I15.3 (novel protein similar to septin) LOC388745 1 LOC388745 LOC347813 1q42.12 hypothetical protein LOC347813 KIAA0483 1q42.12 KIAA0483 protein LOC388746 1 LOC388746 DEGS 1q41 degenerative spermatocyte homolog, lipid desaturase (Drosophila) NVL 1q41-q42.2 nuclear VCP-like HSPC163 1q42.12 HSPC163 protein WDR26 1q42.12-q42.13 WD repeat domain 26 FLJ38993 1q42.13 hypothetical protein FLJ38993 MGC27277 1q42.13 hypothetical protein MGC27277 LOC388747 1 similar to RIKEN cDNA A230079K17 LOC127602 1q42.13 similar to KIAA1697 protein LBR 1q42.1 lamin B receptor ENAH 1q41 enabled homolog (Drosophila) SRP9 1q42.13 signal recognition particle 9kDa LEFTY3 1q42.1 LEFTY family pseudogene EPHX1 1q42.1 epoxide hydrolase 1, microsomal (xenobiotic) KIAA0792 1q42.13 epoxide hydrolase 1, microsomal (xenobiotic) LEFTB 1q42.1 left-right determination, factor B P5CR2 1q42.13 pyrroline 5-carboxylate reductase isoform EBAF 1q42.1 endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily) FLJ35382 1q42.13 hypothetical protein FLJ35382 H3F3A 1q41 H3 histone, family 3A ACBD3 1q42.13 acyl-Coenzyme A binding domain containing 3 MIXL1 1q41 Mix1 homeobox-like 1 (Xenopus laevis) TGS 1q42.13 TUDOR gene similar ADPRT 1q42 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) LOC391168 1 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC391169 1 similar to hypothetical protein D11Ertd497e LOC388748 1 LOC388748 LOC388749 1 LOC388749 ITPKB 1q41-q42 inositol 1,4,5-trisphosphate 3-kinase B LOC391170 1 similar to hypothetical protein PSEN2 1q42.1 presenilin 2 (Alzheimer disease 4) CABC1 1q42.11 chaperone, ABC1 activity of bc1 complex like (S. pombe) CDC42BPA 1q42.11 CDC42 binding protein kinase alpha (DMPK-like)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - - - 2008 18676769
  • contains an additional exon corresponding to 21 AAs located in the EVH2 domain, from a breast carcinoma cell line of epithelial phenotype
  • specifically associated with an epithelial phenotype, EGFR dependency, and sensitivity to erlotinib (Pino 2008)
  • role in coupling multiple signaling pathways involved in breast cancer
  • activated by EGFR in breast cancer cell lines
  • 15 - 13172 66.4 591 - 2008 19081071
    14 - 13109 63.8 570 - 2007 18158903
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ENA/VASP homology domain (EVH1) at the N terminus
  • an arg-leu-glu-rich region
  • a pro-rich profilin binding motif
  • C terminal EVH2 domain
  • HOMOLOGY
    interspecies homolog to murine enabled homolog
    ortholog to drosophila Ena
    Homologene
    FAMILY
  • Ena/VASP family
  • enabled/vasodilator-stimulated phosphoprotein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulating lamellipodial dynamics and actin network
  • actin regulatory protein involved in the control of cell motility and adhesion, and modulated during human breast carcinogenesis
  • have a role beyond anticapping activity in filopodia formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of the EVH1 domain with FPPPP sequence motifs found in a variety of cytoskeletal proteins, including lamellipodin, vinculin, and zyxin
  • ZYX recruits Enabled/vasodilator-stimulated phospho-proteins (ENAH/VASP) to promote actin assembly
  • interaction with ABI1 (promotes the ABL-mediated phosphorylation of ENAH by binding both ABL and ENAH)
  • by mediating intensive F-actin accumulation at the sites of cell infiltration, WASF2, WASL, and ENAH are crucial for PI3K-dependent cell invasion induced by PDGFA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in high-risk benign breast lesions and primary and metastatic tumors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS