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FLASH GENE

Symbol

EMR3

contributors: - updated : 23-03-2007

HGNC name	egf-like module containing, mucin-like, hormone receptor-like 3
HGNC id	23647

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.1      Physical location : 14.730.051 - 14.785.730

DNA

TYPE	functioning gene
STRUCTURE	55.00 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed EMR3 Ia - splicing 2390 EMR3 Ia 72 652 - Bjarnadóttir transcript containing 16 exons having exon 4a (longer than 4b) one Ca-binding EGF-like domain coding for the longest product EMR3 Ib - splicing 2349 EMR3 Ib 13 125 - Bjarnadóttir transcript containing 15 exons having exon 4b (shorter than 4a) lacking exon 5 soluble missing fifty one amino acids missing the Ca-bindind EGF-like domain coding for the shortest product

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Hearing/Equilibrium ear inner cochlea   highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Ca-binding EGF-like domain
	a TM7 domain
	a mucin-like spacer domain
	a GPS domain

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY	G-protein coupled receptor 2 family
	LN-TM7 subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

may be playing a role in myeloid-myeloid interactions during immune and inflammatory responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS