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FLASH GENE
Symbol EMR2 contributors: mct - updated : 01-09-2010
HGNC name egf-like module containing, mucin-like, hormone receptor-like 2
HGNC id 3337
Location 19p13.12      Physical location : 14.843.204 - 14.889.353
Synonym name
  • egf-like module containing, mucin-like, hormone receptor-like sequence 2
  • EGF-like module receptor 2
  • CD312 antigen
  • Synonym symbol(s) CD312, DKFZp781B135
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, opposite orientation
    text
  • clustered with other EMR (1, 3 or 4) and CD97
  • in opposite direction with CD97
  • STRUCTURE 46.15 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - RFX1 RFX1 - CD97 - EMR2 - NOTCH3 - RAB8A - cen
    Authors Lin (00)
    RNA
    TRANSCRIPTS type messenger
    text two chimeric variants produced by trans-splicing between EMR2 and CD97 (Chiu 2008)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 splicing 6771 90.5 823 - Lin, Stacey (2003)
  • also called variant 1/isoform a
  • having exon 13a (longer than 13b)
  • four EGF-like domains
  • coding for the longest product
  • 20 splicing 6624 85.1 774 - Lin, Stacey (2003)
  • also called variant 2/isoform b
  • having exon 13a (longer than 13b)
  • lacking exon 7
  • three EGF-like domains
  • 19 splicing 6492 80.2 730 - Lin, Stacey (2003)
  • also called variant 3/isoform c
  • having exon 13a (longer than 13b)
  • lacking exons 6 & 7
  • two EGF-like domains
  • 18 splicing 6345 74.8 681 - Lin, Stacey (2003)
  • also called variant 4/isoform d
  • having exon 13a (longer than 13b)
  • lacking exons 6, 7 & 8
  • one EGF-like domain
  • coding for the shortest product
  • 21 splicing 6738 89.3 812 - Lin, Stacey (2003)
  • also called variant 5/isoform e
  • having exon 13b (shorter than 13a)
  • four EGF-like domains
  • 20 splicing 6591 84.1 763 - Lin, Stacey (2003)
  • also called variant 6/isoform f
  • having exon 13b (shorter than 13a)
  • lacking exon 7
  • three EGF-like domains
  • 19 splicing 6459 79.2 719 - Lin, Stacey (2003)
  • also called variant 7/isoform g
  • having exon 13b (shorter than 13a)
  • lacking exons 6 & 7
  • two EGF-like domains
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    cell lineage myeloid cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • five tandem EGF-like domains, mediating cell attachment through chondroitin sulfate glycosaminoglycans
  • several potential N and O glycosylation sites
  • a seven-span transmembrane segment (7TM)
  • a mucin-like spacer domain
  • a GPS domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to CD98
    Homologene
    FAMILY
  • rhodopsin family of G protein coupled receptor
  • G-protein coupled receptor 2 family
  • LN-TM7 subfamily
  • CATEGORY regulatory , receptor nuclear membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text rapidly translocated to membrane ruffles and the leading edge of the cell (Yona 2008)
    basic FUNCTION
  • receptor probably involved in cell attachment
  • having a unique function in cells of monocyte and granulocyte lineages
  • playing a role in the migration and adhesion of myeloid cells during cell differentiation, maturation, and activation
  • regulates neutrophil responses by potentiating the effects of a number of proinflammatory mediators (Yona 2008)
  • important role in potentiating the inflammatory response (Yona 2008)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text monocytes and granulocytes
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with chondroitin sulphate glycosaminoglycans in an isoform-specific manner
  • cell & other
    REGULATION
    Other expression of EMR2 is highly regulated, depending on the differentiation/maturation stages of the cells and specific cytokine signaling pathways
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on circulating neutrophils in patients with systemic inflammation (Yona 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS