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FLASH GENE
Symbol EMR1 contributors: - updated : 23-03-2007
HGNC name egf-like module containing, mucin-like, hormone receptor-like sequence 1
HGNC id 3336
Location 19p13.3      Physical location : 6.887.581 - 6.940.463
Synonym symbol(s) TM7LN3
DNA
TYPE functioning gene
STRUCTURE 52.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3150 97 886 - -
- splicing 2966 - 821 - Bjarnadóttir
  • sixty eight amino acids missing in the 7TM
  • coding for a non-fonctional product
  • - splicing 3056 - 867 - Bjarnadóttir
  • missing fifty two amino acids between EGF-like domains 1 and 2
  • a stop codon and thirty three amino acids inserted in the 7TM domain
  • coding for a non-fonctional product
  • - splicing 635 - - - Bjarnadóttir
  • missing the whole C-ter end
  • one EGF-like domain
  • a frame shift after the EGF-like domain 1
  • coding for a non-fonctional product
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five EGF-like domains
  • a seven-span transmembrane segment (7tm_2)
  • a G-protein-coupled receptor proteolytic site domain (GPS)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog EMR1 (74.79 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor superfamily
  • LN-TM7 subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • coupling with Gs alpha protein
  • activating adenylate cyclase
  • could be involved in cell-cell interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS