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FLASH GENE
Symbol EMR1 contributors: - updated : 23-03-2007
HGNC name egf-like module containing, mucin-like, hormone receptor-like sequence 1
HGNC id 3336
Location 19p13.3      Physical location : 6.887.581 - 6.940.463
Synonym symbol(s) TM7LN3
DNA
TYPE functioning gene
STRUCTURE 52.00 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 CLPP 19p13.2 ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli) SPATA11 19p13.3 spermatogenesis associated 11 PSPN 19p13.3 persephin GTF2F1 19p13.3 general transcription factor IIF, polypeptide 1, 74kDa LOC390877 19 similar to adenylate kinase (EC 2.7.4.3), cytosolic - common carp KHSRP 19p13.3 KH-type splicing regulatory protein (FUSE binding protein 2) MGC34725 19p13.3 hypothetical protein MGC34725 MGC2615 19p13.3 hypothetical protein MGC2615 CRB3 19p13.3 crumbs homolog 3 (Drosophila) FLJ22757 TUBB5 19p13.3 tubulin, beta, 5 TNFSF9 19p13.3 tumor necrosis factor (ligand) superfamily, member 9 TNFSF7 19p13 tumor necrosis factor (ligand) superfamily, member 7 LOC390878 19 similar to 60S ribosomal protein L7 TNFSF14 19p13.3 tumor necrosis factor (ligand) superfamily, member 14 C3 19p13.3 complement component 3 GPR108 19p13.3 G protein-coupled receptor 108 TRIP10 19p13.3 thyroid hormone receptor interactor 10 SH2D3A 19p13.3 SH2 domain containing 3A VAV1 19p13.3 vav 1 oncogene EMR1 19p13.3 egf-like module containing, mucin-like, hormone receptor-like sequence 1 EMR4 19p13.3 egf-like module containing, mucin-like, hormone receptor-like 4 LOC284428 19p13.3 similar to methyl-CpG binding domain protein 3-like 2 MBD3L2 19p13.3 methyl-CpG binding domain protein 3-like 2 LOC388498 19 similar to methyl-CpG binding domain protein 3-like 2 MGC4054 19p13.3 hypothetical protein MGC4054 INSR 19p13.3-p13.2 insulin receptor P114-RHO-GEF 19p13.3 insulin receptor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3150 97 886 - -
- splicing 2966 - 821 - Bjarnadóttir
  • sixty eight amino acids missing in the 7TM
  • coding for a non-fonctional product
  • - splicing 3056 - 867 - Bjarnadóttir
  • missing fifty two amino acids between EGF-like domains 1 and 2
  • a stop codon and thirty three amino acids inserted in the 7TM domain
  • coding for a non-fonctional product
  • - splicing 635 - - - Bjarnadóttir
  • missing the whole C-ter end
  • one EGF-like domain
  • a frame shift after the EGF-like domain 1
  • coding for a non-fonctional product
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five EGF-like domains
  • a seven-span transmembrane segment (7tm_2)
  • a G-protein-coupled receptor proteolytic site domain (GPS)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog EMR1 (74.79 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor superfamily
  • LN-TM7 subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • coupling with Gs alpha protein
  • activating adenylate cyclase
  • could be involved in cell-cell interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS