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FLASH GENE
Symbol EMP1 contributors: mct - updated : 25-04-2007
HGNC name epithelial membrane protein 1
HGNC id 3333
Location 12p12.3      Physical location : 13.349.601 - 13.369.707
Synonym name
  • tumor associated membrane protein
  • protein B4B
    • Synonym symbol(s) CL20, TMP, CL-20, EMP-1, B4B
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine  highly
     liver   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveproliferating cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		four transmembrane domains, homologous to the PMP22 protein
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rabbit CL-20
    intraspecies homolog to PMP22
    Homologene
    FAMILY PMP22/EMP/MP20 family of membrane glycoprotein
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • c-Myc target
  • playing a role as a biomarker of gefitinib clinical resistance, and also involved in the EGFR signaling pathway
  • TJ-associated protein of the BBB (blood-brain barrier) and with potential role in the regulation of the BBB function in cerebral ischemia (Bangsow 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EGFR signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target biomarker of gefitinib resistance in lung cancer
    ANIMAL & CELL MODELS