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FLASH GENE
Symbol EML4 contributors: mct - updated : 06-09-2007
HGNC name echinoderm microtubule associated protein like 4
HGNC id 1316
Location 2p22-p21      Physical location : 42.396.489 - 42.559.686
Synonym name
  • restrictely overexpressed proliferation, associated protein 120
  • chromosome 2 open reading frame 2
  • EMAP-like protein 4
  • Synonym symbol(s) FLJ10942, ROPP120, C2orf2 , ELP120
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 163.00 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
     thyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G1, S, G2
    life cycle G0
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal portion (AA 1-249) is essential for the association with microtubules
  • four WD40 repeats
  • a conserved consensus sequence of serine protease
  • a histidine and phosphatase site
  • an EF-hand calcium binding domain
  • N glycosylation and more than phosphorylation sites
  • conjugated PhosphoP
    HOMOLOGY
    intraspecies homolog to EML1
    Homologene
    FAMILY EMAP-like proteins family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION playing a necessary role for correct microtubule formation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hodgkin lymphoma
    tumoral fusion      
    EML4-ALK in non-small-cell lung cancer (NSCLC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS