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FLASH GENE
Symbol EML2 contributors: - updated : 03-03-2007
HGNC name echinoderm microtubule associated protein like 2
HGNC id 18035
Location 19q13.32      Physical location : 46.112.659 - 46.148.775
Synonym name echinoderm MT-associaated protein (EMAP)-like protein 70
Synonym symbol(s) ELP70, EMAP2, EMAP-2
DNA
TYPE functioning gene
STRUCTURE 30.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC2650 19q13.32 hypothetical protein MGC2650 LOC388552 19 similar to BC043666 protein XTP7 19q13.32 protein 7 transactivated by hepatitis B virus X antigen (HBxAg) MARK4 19q13.2 MAP/microtubule affinity-regulating kinase 4 CKM 19q13.2 creatine kinase, muscle LOC390943 19 similar to 40S ribosomal protein S16 KLC2L 19q13.3 similar to 40S ribosomal protein S16 ERCC2 19q13.3 excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) RAI 19q13.32 RelA-associated inhibitor ASE-1 19q13.3 RelA-associated inhibitor ERCC1 19q13.3 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) FOSB 19q13.3 FBJ murine osteosarcoma viral oncogene homolog B RTN2 19q13.3 reticulon 2 VASP 19q13.2-q13.3 vasodilator-stimulated phosphoprotein FLJ40125 19q13.32 hypothetical protein FLJ40125 OPA3 19q13.32 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) GPR4 19q13.3 G protein-coupled receptor 4 EML2 19q13.32 echinoderm microtubule associated protein like 2 GIPR 19q13.3 gastric inhibitory polypeptide receptor SNRPD2 19q13.2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa FLJ20084 19q13.32 hypothetical protein FLJ20084 20D7-FC4 LOC388553 19 LOC388553 SIX5 19q13.3 sine oculis homeobox homolog 5 (Drosophila) DMPK 19q13.3 dystrophia myotonica-protein kinase DMWD 19q13.3 dystrophia myotonica-containing WD repeat motif RSHL1 19q13.3 radial spokehead-like 1 SYMPK 19q13.32 symplekin FOXA3 19q13.2-q13.4 forkhead box A3 IRF2BP1 19q13.32 interferon regulatory factor 2 binding protein 1 LOC339344 19q13.32 hypothetical protein LOC339344 NANOS2 19q13.32 nanos homolog 2 (Drosophila) NOVA2 19q13.3 neuro-oncological ventral antigen 2 LOC388554 19 similar to BC282485_1 PGLYRP 19q13.2-q13.3 peptidoglycan recognition protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineparathyroid   highly
Lymphoid/Immunethymus   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 11 WD repeats
  • a highly conserved hydrophobic ELP domain
  • HOMOLOGY
    Homologene
    FAMILY EMAP family of WD-repeat proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,nucleus,chromatin/chromosome
    text mitotic apparatus
    basic FUNCTION
  • may be modifying the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS