Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

EMG1

contributors: mct/npt/pgu - updated : 22-08-2009

HGNC name	EMG1 nucleolar protein homolog (S. cerevisiae)
HGNC id	16912

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	BWCNS Bowen-Conradi syndrome
Location	12p13.31      Physical location : 7.079.943 - 7.085.165
Synonym name	probable ribosome biogenesis protein NEP1
	C2f protein
	essential for mitotic growth 1
	nucleolar protein EMG1 homolog
Synonym symbol(s)	NEP1, C2F, Grcc2f, FLJ60792

DNA

TYPE	functioning gene
STRUCTURE	5.15 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006331 6 - 1068 NP_006322 - 244 - 2009 19463982

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Digestive liver       highly Endocrine pancreas       highly Reproductive female system placenta     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

Text	brain, lung, liver, kidney, spleen, thymus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved SPOUT core
	two unique domains that form an extended surface, which we predict to be involved in binding of RNA substrates

conjugated

Other

mono polymer

homomer , dimer

HOMOLOGY

interspecies

ortholog to murine Grcc2f

Homologene

FAMILY

alpha/beta knot fold methyltransferase (SPOUT) superfamily

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus
text	distributed throughout the cell; however, its nuclear localization depends on physical interaction with a newly characterized nucleolar protein, NOL14

basic FUNCTION	acting as a translation elongation factor
	involved in 40S ribosomal subunit biogenesis
	seems to play a role a methylation reaction in pre-rRNA processing
	essential for the biogenesis of 18S ribosomal RNA and the 40S ribosome
	essential function in ribosomal biogenesis which directly or indirectly interferes with a methylation reaction during the early steps of pre-rRNA processing necessary for the generation of 40S ribosomal subunits
	presence of the protein is both necessary and sufficient for ribosome biogenesis
	essential ribosome assembly factor

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

acetylated

INTERACTION

DNA

RNA

small molecule

protein

interaction with NOL14 (interaction is required for the maturation of the 18S rRNA and for 40S ribosome production)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

BWCNS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS