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FLASH GENE
Symbol EMC8 contributors: mct - updated : 22-03-2016
HGNC name ER membrane protein complex subunit 8
HGNC id 7864
Location 16q24.1      Physical location : -
Synonym name
  • chromosome 16 open reading frame 4
  • chromosome 16 open reading frame 2
  • family with sequence similarity 158, member B
  • COX4 neighbor C16orf2, C16orf4, COX4NB, FAM158B, NOC4
  • Synonym symbol(s) C16orf4, NOC4, FAM158B, COX4AL, C16orf2, COX4NB, FAM158B
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 20.87 kb     5 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure bidirectionnal promoter, for both COX4NB and COX4, containing multiples potential SP1 and NRF2 binding sites
    MAPPING cloned N linked N status provisional
    Map cen - D16S422 - D16S3037 - COX4NB - D16S3026 - qter
    Authors Gene Map (98)
    regionally located in 5' of the COX4 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1869 - 126 - 1999 10337626
    5 - 1964 - 210 - 1999 10337626
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver    
    Endocrinepancreas   highly
    Nervousbrain    
    Reproductivefemale systemplacenta  moderately
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Cox4nb
    ortholog to rattus Noc4
    Homologene
    FAMILY
  • NOC4 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • EMC1, EMC3, EMC8, EMC9 are key factors in the biogenesis of multi-pass transmembrane proteins, including RHO, and loss causes retinal degeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS