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FLASH GENE
Symbol EMC3 contributors: mct - updated : 22-03-2016
HGNC name ER membrane protein complex subunit 3
HGNC id 23999
Location 3p25.3      Physical location : -
Synonym name
  • 30 kDa protein
  • partial optokinetic response b
  • transmembrane protein 111
  • Synonym symbol(s) POB, TMEM111
    DNA
    TYPE functioning gene
    STRUCTURE 48.43 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1107 29.8 261 - 2009 19797678
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • is part of the endoplasmic reticulum-associated secretory pathway
  • EMC1, EMC3, EMC8, EMC9 are key factors in the biogenesis of multi-pass transmembrane proteins, including RHO, and loss causes retinal degeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS