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FLASH GENE
Symbol EMC10 contributors: mct - updated : 22-03-2016
HGNC name ER membrane protein complex subunit 10
HGNC id 27609
Location 19q13.33      Physical location : -
Synonym name
  • hematopoietic signal peptide-containing secreted 1
  • hematopoietic signal peptide-containing membrane domain-containing 1
  • chromosome 19 open reading frame 63
  • Synonym symbol(s) INM02, HSS1, HSM1, MGC33203, C19orf63
    DNA
    TYPE functioning gene
    STRUCTURE 29.45 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2211 26.7 254 - 2011 20680400
    HSS1
    7 - 2124 27.2 262 - 2011 20680400
    HSM1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas     Rattus norvegicus
    Reproductivemale systemtestis    Rattus norvegicus
    Urinarybladder     Rattus norvegicus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Rattus norvegicus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • is likely is associated with functions of pancreatic islets, especially of beta-cells
  • is a truly novel protein defining a new class of secreted factors, and it may have an important role in cancer, particularly glioma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    modulates signaling pathways involved in tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    is a potential therapeutic for malignant glioblastoma possessing significant antitumor and anti-angiogenic activity
    ANIMAL & CELL MODELS