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FLASH GENE
Symbol ELP6 contributors: mct - updated : 27-02-2017
HGNC name elongator acetyltransferase complex subunit 6
HGNC id 25976
Location 3p21.31      Physical location : -
Synonym name
  • angiotonin-transactivated protein 1
  • transmembrane protein 103
  • Synonym symbol(s) FLJ20211, ATP1, C3orf75, TMEM103
    DNA
    TYPE functioning gene
    STRUCTURE 18.10 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1374 29.6 266 - 2013 24284306
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnerve    
    Reproductivefemale systemovary   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil Homo sapiensAdult
    Blood/Hematopoieticmonocyte Homo sapiensAdult
    Blood/Hematopoieticneutrophil Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • ELP4, ELP5, and ELP6--are required for histone acetyltransferase (HAT) activity, and Elongator binds to both naked and nucleosomal DNA
  • plays an important role in RNA polymerase II-mediated transcriptional elongation and many other processes, including cytoskeleton organization, exocytosis, and tRNA modification 6)
  • ELP5 and ELP6 are key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator
  • ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 plays vital roles in gene regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • acts as a bridge to assemble ELP4 and ELP5 6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS