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FLASH GENE
Symbol ELP5 contributors: mct - updated : 27-02-2017
HGNC name elongator acetyltransferase complex subunit 5
HGNC id 30617
Location 17p13.1      Physical location : -
Synonym name
  • S-phase 2 protein
  • dermal papilla derived protein 6
  • chromosome 17 open reading frame 81
  • Synonym symbol(s) HSPC002, DERP6, MST071, MSTP071, c17orf81
    DNA
    TYPE functioning gene
    STRUCTURE 7.89 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1437 - 316 - 2006 16850183
    nine exons
    7 - 2223 - 279 - 2006 16850183
    seven exons
    8 - 1525 - 316 - 2006 16850183
    eight exons
    9 - 1322 - 316 - 2006 16850183
    nine exons
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestiveliver     Homo sapiens
    Nervousbrainhindbraincerebellum  
    Reproductivemale systemtestis    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Rai12
    ortholog to rattus derp6
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • interacting with proteins involded in the network for human inherited ataxias and disorders of Purkinje cell degeneration
  • ELP4, ELP5, and ELP6--are required for histone acetyltransferase (HAT) activity, and Elongator binds to both naked and nucleosomal DNA
  • may be involved in p53-mediated gene transcription
  • plays an important role in RNA polymerase II-mediated transcriptional elongation and many other processes, including cytoskeleton organization, exocytosis, and tRNA modification 6)
  • ELP5 and ELP6 are key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator
  • ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 plays vital roles in gene regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core Elongator complex formed by IKBKAP, ELP2, and ELP3 was rather stable, whereas ELP4, ELP5, and ELP6 might loosely contact and work together with the core Elongator to regulate cell functions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ELP6 acts as a bridge to assemble ELP4 and ELP5 6)
  • is required for the integrity of Elongator and directly connects ELP3 to ELP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS