basic FUNCTION
| involved in the biosynthesis of very long chain fatty acids |
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essential for the synthesis of epidermal very long-chain FA (VLFA), and required for generating -O-acylceramides, a key ceramide molecular species that is essential for permeability barrier function |
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involved in fatty acid elongation, and required for the synthesis of C28 and C30 saturated fatty acids (VLC-FA) and of C28-C38 very long chain polyunsaturated fatty acids (VLC-PUFA), the latter being uniquely expressed in retina, sperm, and brain (mainly present in retinal outer segment membranes in phosphatidylcholine) |
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likely involved in the elongation of C26 and longer fatty acids  |
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elongase involved in the production of extremely long-chain fatty acids  |
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is essential for very long chain polyunsaturated fatty acid (VLC-PUFA) synthesis as well as retinal functions  |