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FLASH GENE
Symbol ELMO3 contributors: mct/npt - updated : 25-08-2014
HGNC name engulfment and cell motility 3
HGNC id 17289
Location 16q22.1      Physical location : 67.233.027 - 67.237.926
Synonym name
  • engulfment and cell motility 3 (ced-12 homolog, C. elegans)
  • ced-12 homolog 3
  • Synonym symbol(s) FLJ13824, CED12, ELMO-3, CED-12
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 4.90 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • SP1-binding sites are likely to play an important role in regulating the ELMO3 promoter activity
  • MAPPING cloned Y linked N status confirmed
    Physical map
    FLJ35894 16q22.1 hypothetical protein FLJ35894 APPBP1 16q22 amyloid beta precursor protein binding protein 1, 59kDa CA7 16q22.1 carbonic anhydrase VII KIAA1348 CDH16 16q22.1 cadherin 16, KSP-cadherin RRAD 16q22 Ras-related associated with diabetes CGI-128 16q22.1-q22.3 CGI-128 protein CES2 16q22.1 carboxylesterase 2 (intestine, liver) FLJ21736 16q22.1 esterase 31 FLJ37464 16q22.1 hypothetical protein FLJ37464 CBFB 16q22.1 core-binding factor, beta subunit Lin10 16q22.1 lin-10 protein homolog MGC4655 16q22.1 hypothetical protein MGC4655 TRADD 16q22 TNFRSF1A-associated via death domain FBXL8 16q23.1 F-box and leucine-rich repeat protein 8 HSF4 16q21 heat shock transcription factor 4 NOL3 16qp21-q23 nucleolar protein 3 (apoptosis repressor with CARD domain) LOC283849 16q22.1 hypothetical protein LOC283849 E2F4 16q22.1 E2F transcription factor 4, p107/p130-binding ELMO3 16q23.1 engulfment and cell motility 3 (ced-12 homolog, C. elegans) FBXL9 16q23-q31 F-box and leucine-rich repeat protein 9 HSPC171 16q22.1 HSPC171 protein FHOD1 16q22 formin homology 2 domain containing 1 SLC9A5 16q22.1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 5 DKFZP434I216 16q22.1 DKFZP434I216 protein FLJ40162 16q22.1 FLJ40162 protein FLJ11004 16q22.1 hypothetical protein FLJ11004 CGI-38 16q22.1 brain specific protein ZDHHC1 16q23.1 zinc finger, DHHC domain containing 1 HSD11B2 16q22 hydroxysteroid (11-beta) dehydrogenase 2 ATP6V0D1 16q22 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1 AGRP 16q22.1 agouti related protein homolog (mouse) FLJ13725 16q22.1 hypothetical protein FLJ13725 CTCF 16q22.1 CCCTC-binding factor (zinc finger protein)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2548 - 773 - 2001 11595183
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • an ELMO domain
  • a PH domain
  • HOMOLOGY
    interspecies ortholog to C.elegans
    ortholog to Drosophila Ced12
    intraspecies paralog to ELMO1,ELMO2
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • upstream regulator of AKT1 required for engulfment of dying cells and for cell migration
  • involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility
  • unexpected role for ELMO1, ELMO2, ELMO3 in recruiting MACF1 at the membrane to promote efficient microtubule capture in cells spreading on fibronectin
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling
    signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
  • is an essential upstream regulator of the GTP-binding protein AKT1 during cell migration
  • CDX2 and SP1 can activate the ELMO3 promoter
  • MACF1 interacts with ELMO2 and ELMO3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS