Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ELL3 contributors: mct - updated : 29-08-2014
HGNC name elongation factor RNA polymerase II-like 3
HGNC id 23113
Location 15q15.3      Physical location : 44.064.797 - 44.069.502
Synonym symbol(s) FLJ22637
DNA
TYPE functioning gene
STRUCTURE 4.70 kb     11 Exon(s)
MAPPING cloned Y linked N status confirmed
Physical map
CDAN1 15q14-q15 congenital dyserythropoietic anemia, type I TTBK2 15q14 tau tubulin kinase 2 LOC390580 15 similar to Ac2-125 UBR1 15q15-q21.1 ubiquitin protein ligase E3 component n-recognin 1 LOC146053 15q14 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC255320 15q15.1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) FLJ23375 15q15.1 hypothetical protein FLJ23375 CCNDBP1 15q14-q15 cyclin D-type binding-protein 1 EPB42 15q15 erythrocyte membrane protein band 4.2 TGM5 15q15.2 transglutaminase 5 LOC390581 15 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d TGM7 15q15.2 similar to ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d; ATP synthase, H+ transporting, mitochondrial F1F0, subunit d LCMT2 15q14 leucine carboxyl methyltransferase 2 LOC161823 15q15.1 similar to Adenosine deaminase CG11994-PA FLJ35867 15q15.1 hypothetical protein FLJ35867 76P 15q15 gamma tubulin ring complex protein (76p gene) TP53BP1 15q15-q21 tumor protein p53 binding protein, 1 MAP1A 15q13-qter microtubule-associated protein 1A KIAA0377 15q15-q21.2 microtubule-associated protein 1A CKMT1 15q15 creatine kinase, mitochondrial 1 (ubiquitous) STRC 15q15.3 stereocilin CATSPER2 15q13-q15 cation channel, sperm associated 2 GRP58 15q15 glucose regulated protein, 58kDa ELL3 15q15.1 elongation factor RNA polymerase II-like 3 SERF2 15q13.1 small EDRK-rich factor 2 HYPK 15q14 small EDRK-rich factor 2 MFAP1 15q15-q21 microfibrillar-associated protein 1 FLJ12973 15q15.1 hypothetical protein FLJ12973 MGC14161 15q15.1 hypothetical protein MGC14161 ACTBP7 15q15.3 actin, beta pseudogene 7 H63 15q15.1 H63 breast cancer expressed gene HSPC129 15q15.1 hypothetical protein HSPC129 EIF3S1 15q15.3 eukaryotic translation initiation factor 3, subunit 1 alpha, 35kDa FLJ21439 15q14 hypothetical protein FLJ21439 LOC197135 15q15.1 similar to RIKEN cDNA 4930424G05
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2127 - 397 - 2000 10882741
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemtestis  highly Homo sapiens
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain shows strong similarities to that of ELL, which acts as a negative regulator of TP53 and regulates cell proliferation and survival
  • HOMOLOGY
    interspecies homolog to rattus Ell3 (78.3 pc)
    homolog to murine Ell3 (77.7 pc)
    Homologene
    FAMILY
  • ELL/occludin family
  • Ell (eleven-nineteen lysine-rich leukemia gene) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • increasing the catalytic rate of RNA polymerase II transcription elongation by suppressing transient pausing by the polymerase at multiple sites along the DNA
  • promotes the differentiation of ESCs by activating the expression of EMT-related genes and by suppressing TP53 expression
  • unique role for ELL3 at enhancers for the priming of gene activation during stem cell specification
  • could prime gene activation by marking enhancers as early as in the germ cells
  • enhancer-associated ELL3 is essential for stem cell specification
  • might potentially serve as an epigenetic marker in germ cells by bookmarking the inactive enhancers of genes for future activation in the embryo
  • RNA polymerase II transcription elongation factor that is enriched in testis
  • may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway
  • CELLULAR PROCESS nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
  • transcription elongation factor complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates Pol II occupancy at promoter-proximal regions of neighboring genes
  • can interact with AFF4 and CCNT1 when overexpressed in ES cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS