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FLASH GENE
Symbol ELL3 contributors: mct - updated : 29-08-2014
HGNC name elongation factor RNA polymerase II-like 3
HGNC id 23113
Location 15q15.3      Physical location : 44.064.797 - 44.069.502
Synonym symbol(s) FLJ22637
DNA
TYPE functioning gene
STRUCTURE 4.70 kb     11 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2127 - 397 - 2000 10882741
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemtestis  highly Homo sapiens
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal domain shows strong similarities to that of ELL, which acts as a negative regulator of TP53 and regulates cell proliferation and survival
  • HOMOLOGY
    interspecies homolog to rattus Ell3 (78.3 pc)
    homolog to murine Ell3 (77.7 pc)
    Homologene
    FAMILY
  • ELL/occludin family
  • Ell (eleven-nineteen lysine-rich leukemia gene) family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • increasing the catalytic rate of RNA polymerase II transcription elongation by suppressing transient pausing by the polymerase at multiple sites along the DNA
  • promotes the differentiation of ESCs by activating the expression of EMT-related genes and by suppressing TP53 expression
  • unique role for ELL3 at enhancers for the priming of gene activation during stem cell specification
  • could prime gene activation by marking enhancers as early as in the germ cells
  • enhancer-associated ELL3 is essential for stem cell specification
  • might potentially serve as an epigenetic marker in germ cells by bookmarking the inactive enhancers of genes for future activation in the embryo
  • RNA polymerase II transcription elongation factor that is enriched in testis
  • may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway
  • CELLULAR PROCESS nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
  • transcription elongation factor complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates Pol II occupancy at promoter-proximal regions of neighboring genes
  • can interact with AFF4 and CCNT1 when overexpressed in ES cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS