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FLASH GENE
Symbol ELL2 contributors: mct/npt - updated : 19-01-2016
HGNC name elongation factor, RNA polymerase II, 2
HGNC id 17064
Location 5q15      Physical location : 95.220.803 - 95.297.775
Synonym name
  • ELL-related RNA polymerase 2, elongation factor
  • elongation factor eleven nineteen lysine-rich leukemia gene 2
  • DNA
    TYPE functioning gene
    STRUCTURE 76.97 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391810 5 similar to T-complex protein 1, eta subunit (TCP-1-eta) (CCT-eta) (HIV-1 Nef interacting protein) LOC391811 5 similar to DNA polymerase delta subunit 2 NR2F1 5q14 nuclear receptor subfamily 2, group F, member 1 LOC389309 5 LOC389309 DKFZP564D172 5q15 hypothetical protein DKFZp564D172 FLJ25680 5q15 hypothetical protein FLJ25680 FLJ12078 5q15 hypothetical protein FLJ12078 KIAA0825 5q15 KIAA0825 protein MGC34713 5q15 hypothetical protein MGC34713 DKFZp761C121 5q15 hypothetical protein DKFZp761C121 FLJ22344 5q15 hypothetical protein FLJ22344 LOC389310 5 LOC389310 FLJ25333 5q15 hypothetical protein FLJ25333 KIAA0372 5q13-q15 hypothetical protein FLJ25333 DKFZp313G1735 5q15 hypothetical protein DKFZp313G1735 LOC285601 5q15 seven transmembrane helix receptor LOC285601 LOC317671 5q15 LOC317671 SPATA9 5q15 spermatogenesis associated 9 RHOBTB3 5q21.2 Rho-related BTB domain containing 3 GLRX 5q14 glutaredoxin (thioltransferase) FIS 5q15 FIS ELL2 1q21-q25 elongation factor, RNA polymerase II, 2 PCSK1 5q15-q21 proprotein convertase subtilisin/kexin type 1 LOC389311 5 LOC389311 CAST 5q15-q21 calpastatin ARTS-1 5q15 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator LRAP 16 leukocyte-derived arginine aminopeptidase FLJ39485 5q15 hypothetical protein FLJ39485 LNPEP 5q21 leucyl/cystinyl aminopeptidase FLJ25534 5q15 hypothetical protein FLJ25534 RIOK2 5q14 RIO kinase 2 (yeast) LOC391812 5 similar to Dermatomyositis associated with cancer putative autoantigen-1 (DACA-1) LOC391813 5 similar to Zinc finger DHHC domain containing protein 3 (Zinc finger protein 373) (DHHC1 protein) LOC389312 5 similar to Proteasome activator complex subunit 2 (Proteasome activator 28-beta subunit) (PA28beta) (PA28b) (Activator of multicatalytic protease subunit 2) (11S regulator complex beta subunit) (REG-beta) LOC391814 5 similar to cytoplasmic beta-actin MRPS35P2 5q15 mitochondrial ribosomal protein S35 pseudogene 2 LOC285703 5q21.1 similar to C-terminal binding protein 2 isoform 2; ribeye LOC391815 5 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FLJ90406 CHD1 5q15-q21 chromodomain helicase DNA binding protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6063 72.3 640 - 2001 11418481
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal elongation activation domain
  • an occludin domain
  • HOMOLOGY
    intraspecies homolog to ELL
    Homologene
    FAMILY
  • ELL family
  • CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be having roles to suppress canonical Wnt signaling in the cytoplasm
  • loading of ELL2 and CSTF2 on RNA polymerase II was linked, caused enhanced use of the proximal poly(A) site and was necessary for processing of immunoglobulin heavy-chain mRNA
  • TCF3 and ELL2, play important roles in the regulation of B cell development in the bone marrow and differentiation of mature B cells into plasma cells in the periphery, respectively
  • HNRNPLL and ELL2 are regulators of pre-mRNA processing in plasma cells
  • has a prominent role as a component of super elongation complex (SEC) in the rapid yet synchronous activation of genes in response to extracellular signals in the presence or absence of paused Pol II
  • transcription elongation factor ELL2 plays an important role in the induction of Ig secretory mRNA production, the unfolded protein response, and gene expression during hypoxia
  • stimulates the processing of the secreted form of the IgH mRNA from the H chain gene
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • multiple lineage leukemia gene (KMT2A) and DOT1L associations with the IgH gene were also impaired in the absence of ELL2
  • RING domain protein SIAH1, but not the homologous SIAH2, is the E3 ubiquitin ligase for ELL2 polyubiquitination and proteasomal degradation
  • ELL2 enhances the expression of TNFRSF17, which is important for long-term survival
  • ELL2 is important for many aspects of Ab secretion, XBP1 expression, and the unfolded protein response (UPR) (
  • PRDM1 induced the transcription of immunoglobulin genes and regulated the post-transcriptional expression switch from the membrane-bound form of the immunoglobulin heavy chain to its secreted form by activating ELL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS