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FLASH GENE
Symbol ELK4 contributors: mct - updated : 09-04-2014
HGNC name ELK4, ETS-domain protein (SRF accessory protein 1)
HGNC id 3326
Location 1q32.1      Physical location : 205.585.234 - 205.602.000
Synonym name
  • ETS-domain protein
  • SRF accessory protein 1
  • serum response factor accessory protein 1
  • Synonym symbol(s) SAP1, SRFAP1
    DNA
    TYPE functioning gene
    STRUCTURE 35.36 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 3077 - 405 - 2004 14770179
    ELK4vb
    5 - 11170 - 431 - 2004 14770179
    ELK4va
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Reproductivemale systemprostate  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ETS DNA-binding motif (Box A)
  • a domain (Box B) mediating the interaction with serum response factor (SRF)
  • a domain (Box C) regulating transcriptional activation, erythroblast transformation specific domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Sap1
    intraspecies homolog to ets protooncogene 4
    Homologene
    FAMILY divergent member of the winged helix-turn-helix superfamily (ETS family of transcription factor)
    CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • transcription regulator
  • requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously
  • ERK signaling to ELK4 is not required for the suppressive activity of T(reg) cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel AR target in human prostate cancer cells
  • ELK4 functions to target SIRT7 to specific promoters for H3K18 deacetylation
  • SRF utilizes MKL1/2 to fulfill steady state cellular functions, including cytoskeletal organization, and utilizes ELK4 to facilitate acute responses to external infection
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with ELK4 in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS