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FLASH GENE
Symbol ELK3 contributors: - updated : 20-05-2006
HGNC name ELK3, ETS-domain protein (SRF accessory protein 2)
HGNC id 3325
Location 12q22-q23.1      Physical location : 96.588.206 - 96.661.606
Synonym name SRF accessory protein 2
Synonym symbol(s) ERP, SAP2, SRFAP2, NET, ELK-3
DNA
TYPE like-sequence
STRUCTURE 72.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6 LOC387875 12 LOC387875 LOC283412 12q23.1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) METAP2 12q22 methionyl aminopeptidase 2 USP44 12q21.33 ubiquitin specific protease 44 NTN4 12q22-q23 netrin 4 SNRPF 12q21.33 small nuclear ribonucleoprotein polypeptide F FLJ40089 12q23.1 hypothetical protein FLJ40089 MGC35366 12q23.1 hypothetical protein MGC35366 HAL 12q22-q23.1 histidine ammonia-lyase LTA4H 12q22 leukotriene A4 hydrolase ELK3 12q22-q23.1 ELK3, ETS-domain protein (SRF accessory protein 2) PCTK2 12q23.1 PCTAIRE protein kinase 2 FLJ31514 12q23.1 hypothetical protein FLJ31514 FLJ44112 12q23.1 FLJ44112 protein LOC387876 12 LOC387876 LOC390352 12 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati NEDD1 12q22 neural precursor cell expressed, developmentally down-regulated 1 LOC121456 12q23.1 similar to solute carrier family 9, member 7; nonselective sodium potassium/proton exchanger; sodium/hydrogen exchanger 7 TMPO 12q22-q23.1 thymopoietin LOC341457 12q23.1 similar to peptidyl-Pro cis trans isomerase SLC25A3 12q22-q23.1 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas    
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuterus  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage cell maturation
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transcription regulator containing the ETS DNA-binding motif (Box A)
  • a domain (Box B) mediating the interaction with serum response factor (SRF)
  • a domain (Box C) regulating transcriptional activation
  • HOMOLOGY
    interspecies homolog to murine Net (Erp)
    intraspecies homolog to ets protooncogene 3
    Homologene
    FAMILY
  • divergent member of the winged helix-turn-helix superfamily
  • ETS family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • may be a negative regulator of transcription, but can activate transcription when coexpressed with RAS, SRC, or MOS
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with NOS2A (important mediator of its expression)
  • cell & other
    REGULATION
    activated by RAS
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS