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FLASH GENE
Symbol ELF5 contributors: mct/ - updated : 04/10/2008
HGNC name E74-like factor 5 (ets domain transcription factor)
HGNC id 3320
Location 11p13      Physical location : 34.500.341 - 34.535.330
Synonym name
  • epithelium-specific Ets 2
  • exonic splicing enhancer 2
  • epithelium-restricted ESE-1-related Ets factor
  • Synonym symbol(s) ESE2
    DNA
    TYPE functioning gene
    STRUCTURE 34.99 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PAX6 11p13 paired box gene 6 (aniridia, keratitis) RCN1 11p13 reticulocalbin 1, EF-hand calcium binding domain LOC390105 11 similar to RIKEN cDNA 0610012H03 WT1 11p13 Wilms tumor 1 WIT-1 11p13 Wilms tumor associated protein LOC387760 11 LOC387760 GA17 11p13 LOC387760 RPL34P2 11p13 ribosomal protein L34 pseudogene 2 TMG4 11p13 transmembrane gamma-carboxyglutamic acid protein 4 FLJ21924 11p13 hypothetical protein FLJ21924 LOC91614 11p13 novel 58.3 KDA protein FLJ11336 11p13 hypothetical protein FLJ11336 PIGCP1 11p13-p12 phosphatidylinositol glycan, class C, pseudogene 1 CSTF3 11p13 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa LOC390107 11 similar to ribosomal protein S24 HIPK3 11p13 homeodomain interacting protein kinase 3 G2 11p13 G2 protein MGC34830 11p13 hypothetical protein MGC34830 CD59 11p13 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) FBXO3 11p12 F-box only protein 3 LOC390108 11 similar to hypothetical protein MGC40611 LMO2 11p13 LIM domain only 2 (rhombotin-like 1) M11S1 11p13 membrane component, chromosome 11, surface marker 1 FLJ10774 11p13 N-acetyltransferase-like protein ABTB2 11p13 ankyrin repeat and BTB (POZ) domain containing 2 CAT 11p13 catalase ELF5 11p15-p13 E74-like factor 5 (ets domain transcription factor) EHF 11p12 ets homologous factor MMRP19 11p13 likely ortholog of mouse monocyte macrophage 19 PDHX 11p13 pyruvate dehydrogenase complex, component X CD44 11p13 CD44 antigen (homing function and Indian blood group system) SLC1A2 11p13-p12 solute carrier family 1 (glial high affinity glutamate transporter), member 2 DKFZP586H2123 11p13 DKFZP586H2123 protein FJX1 11p13 four jointed box 1 (Drosophila) TRIM44 11p12-14 tripartite motif-containing 44 LOC119722 11p13 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LOC143458 11p13 hypothetical protein LOC143458 HSPC166 11p13 HSPC166 protein FLJ14213 11p13 hypothetical protein FLJ14213 TRAF6 11p13-p12 TNF receptor-associated factor 6 RAG1 11p13 recombination activating gene 1 RAG2 11p13 recombination activating gene 2 LOC119710 11p13 hypothetical protein BC009561
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2466 31.1 265 - Choi (2006)
    7 - 2317 30 255 - Choi (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
     salivary gland   highly
     stomach   highly
    Reproductivefemale systembreast   
     male systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Epithelialsecretoryglandular  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text in the placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells (Hemberger 2010)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a negative N regulatory domain at the N-terminus
  • consensus motif with a GGA core and an AT-rich 5'- and 3'-flanking sequences
  • HOMOLOGY
    intraspecies homolog to ELF3
    Homologene
    FAMILY
  • ETS family
  • ESE(epithelium-specific Ets) subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • putative regulator of epithelial cell differentiation
  • possibly involved in humorigenesis
  • potential regulator of target genes
  • functions as a gatekeeper, downstream of initial lineage determination, to reinforce commitment to the trophoblast lineage or to abort this pathway in cells of the embryonic lineage (Hemberger 2010)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    hypermethylated and largely repressed in embryonic stem cells and derived trophoblast cell lines (Hemberger 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS