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FLASH GENE
Symbol ELF5 contributors: mct/ - updated : 04/10/2008
HGNC name E74-like factor 5 (ets domain transcription factor)
HGNC id 3320
Location 11p13      Physical location : 34.500.341 - 34.535.330
Synonym name
  • epithelium-specific Ets 2
  • exonic splicing enhancer 2
  • epithelium-restricted ESE-1-related Ets factor
  • Synonym symbol(s) ESE2
    DNA
    TYPE functioning gene
    STRUCTURE 34.99 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2466 31.1 265 - Choi (2006)
    7 - 2317 30 255 - Choi (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
     salivary gland   highly
     stomach   highly
    Reproductivefemale systembreast   
     male systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Epithelialsecretoryglandular  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text in the placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells (Hemberger 2010)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a negative N regulatory domain at the N-terminus
  • consensus motif with a GGA core and an AT-rich 5'- and 3'-flanking sequences
  • HOMOLOGY
    intraspecies homolog to ELF3
    Homologene
    FAMILY
  • ETS family
  • ESE(epithelium-specific Ets) subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • putative regulator of epithelial cell differentiation
  • possibly involved in humorigenesis
  • potential regulator of target genes
  • functions as a gatekeeper, downstream of initial lineage determination, to reinforce commitment to the trophoblast lineage or to abort this pathway in cells of the embryonic lineage (Hemberger 2010)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    hypermethylated and largely repressed in embryonic stem cells and derived trophoblast cell lines (Hemberger 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS